Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0324 | 1 | 0.5 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0319 | 0.9588 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0319 | 0.9588 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0324 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0319 | 0.9588 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC25 (functional) | > 100 ug ml-1 | Cytotoxic concentration against uninfected CEM cells | ChEMBL. | 9548818 |
CC25 (functional) | > 100 ug ml-1 | Cytotoxic concentration against uninfected CEM cells | ChEMBL. | 9548818 |
CC50 (functional) | > 500 ug ml-1 | Cytotoxic concentration to uninfected vero cells | ChEMBL. | 9548818 |
IC50 (functional) | = 4.2 ug ml-1 | Inhibition of Tomioka strain of herpes simplex virus( Tomioka strain of HSV-1) by quantitative CPE reduction assay in vero cells | ChEMBL. | 9548818 |
IC50 (functional) | = 52.8 ug ml-1 | Inhibitory activity against DM625 strain of zoster virus(VZV) by plaque reduction assay in HFF cells | ChEMBL. | 9548818 |
IC50 (functional) | = 52.8 ug ml-1 | Inhibitory activity against DM625 strain of zoster virus(VZV) by plaque reduction assay in HFF cells | ChEMBL. | 9548818 |
IC50 (functional) | > 100 ug ml-1 | Inhibitory activity against 1RF strain of HIV-1 by plaque reduction assay in CEM cells | ChEMBL. | 9548818 |
IC50 (functional) | > 100 ug ml-1 | Inhibitory activity against 1RF strain of HIV-1 by plaque reduction assay in CEM cells | ChEMBL. | 9548818 |
MTC (functional) | > 320 ug ml-1 | Minimum cytotoxic concentration against uninfected HFF cells | ChEMBL. | 9548818 |
MTC (functional) | > 320 ug ml-1 | Minimum cytotoxic concentration against uninfected HFF cells | ChEMBL. | 9548818 |
SI (functional) | > 6.1 | Selectivity index is the ratio between IC50 (Anti-VZV Activity (DM625 in HFF Cells)) and minimum cytotoxic concentration (against HFF cells) values of the compound | ChEMBL. | 9548818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.