Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.04 | 0.5 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.04 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.5 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.04 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.04 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.04 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.04 | 0.5 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.04 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.5 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.04 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.04 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.04 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.04 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.04 | 0.5 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.04 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.04 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.04 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.04 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity ratio (functional) | = 1.4 | Analgesic activity against phenylquinone induced writhing in mice compared to that of aspirin. | ChEMBL. | 7731014 |
Activity ratio (functional) | = 1.6 | Analgesic activity against acetic acid-induced writhing in the rat compared to that of aspirin. | ChEMBL. | 7731014 |
ED50 (functional) | = 20.5 mg kg-1 | Antinociceptive potency against acetic acid -induced writhing in rat (8 rats/dose) | ChEMBL. | 7731014 |
ED50 (functional) | = 24.6 mg kg-1 | Antinociceptive potency against phenylquinone (PBQ)-induced writhing in mice (8 mice/dose) | ChEMBL. | 7731014 |
ED50 (functional) | = 24.6 mg kg-1 | Antinociceptive potency against phenylquinone (PBQ)-induced writhing in mice (8 mice/dose) | ChEMBL. | 7731014 |
First adverse effect (ADMET) | 0 | First adverse effect was determined from orientative acute toxicity Irwin test (3 mice/dose) at 256 mg/kg ip; ND= Not determined | ChEMBL. | 7731014 |
Inhibition (functional) | = 99 % | Inhibition of phenylquinone induced writhing in mice following 50 mg/kg p.o. | ChEMBL. | 7731014 |
Inhibition (functional) | = 99 % | Inhibition of phenylquinone induced writhing in mice following 50 mg/kg p.o. | ChEMBL. | 7731014 |
Inhibition (functional) | = 100 % | Inhibition of acetic acid induced writhing in rat following 50 mg/kg p.o. | ChEMBL. | 7731014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.