Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Staphylococcus aureus | Beta-lactamase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | Get druggable targets OG5_143180 | All targets in OG5_143180 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | Get druggable targets OG5_143180 | All targets in OG5_143180 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | beta lactamase | Beta-lactamase | 281 aa | 279 aa | 31.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.0021 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0077 | 0.4012 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.016 | 1 | 1 |
Trypanosoma brucei | beta lactamase | 0.0077 | 0.4012 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | The compound was evaluated for inhibition against class C beta-lactamase derived from Enterobacter cloacae P99; Not tested | ChEMBL. | 10853646 |
IC50 (binding) | 0 uM | The compound was evaluated for inhibition against class C beta-lactamase derived from Enterobacter cloacae P99; Not tested | ChEMBL. | 10853646 |
IC50 (binding) | = 15.4 uM | Inhibition of class A beta-lactamase derived from Staphylococcus aureus strain PC1 | ChEMBL. | 10853646 |
IC50 (binding) | = 15.4 uM | Inhibition of class A beta-lactamase derived from Staphylococcus aureus strain PC1 | ChEMBL. | 10853646 |
IC50 (binding) | = 311 uM | Inhibition of class A TEM-1 beta-lactamase derived from Enterobacter cloacae | ChEMBL. | 10853646 |
IC50 (binding) | = 311 uM | Inhibition of class A TEM-1 beta-lactamase derived from Enterobacter cloacae | ChEMBL. | 10853646 |
NT (binding) | uM | The compound was evaluated for inhibition against the GC1 extended spectrum class C beta-lactamase; Not tested | ChEMBL. | 10853646 |
NT (binding) | 0 uM | The compound was evaluated for inhibition against the GC1 extended spectrum class C beta-lactamase; Not tested | ChEMBL. | 10853646 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.