Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fibrillin 1 | 0.027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.5 | 0.5 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.027 | 0.5 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.027 | 0.5 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.027 | 0.5 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.5 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.027 | 0.5 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.027 | 0.5 | 0.5 |
Echinococcus granulosus | laminin | 0.027 | 0.5 | 0.5 |
Echinococcus multilocularis | laminin | 0.027 | 0.5 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.027 | 0.5 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.027 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.5 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.027 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.027 | 0.5 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.027 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.8 uM | Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5. | ChEMBL. | No reference |
Ki (binding) | = 2.8 uM | Tested for the Inhibition of the catalytic activity of human Thrombin at 25 degree C and pH 7.5. | ChEMBL. | No reference |
Ki (binding) | > 500 uM | Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5. | ChEMBL. | No reference |
Ki (binding) | > 500 uM | Tested for the Inhibition of the catalytic activity of human plasmin at 25 degree C and pH 7.5. | ChEMBL. | No reference |
Ki (binding) | > 500 uM | Tested for the Inhibition of the catalytic activity of bovine trypsin at 25 degree C and pH 7.5. | ChEMBL. | No reference |
Ki (binding) | > 500 uM | Tested for the Inhibition of the catalytic activity of human plasmin at 25 degree C and pH 7.5. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.