Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cysteinyl leukotriene receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | DNA topoisomerase 2 | 0.0137 | 0.8044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4531 | 0.3492 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0137 | 0.8044 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0137 | 0.8044 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0093 | 0.452 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 0.2551 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.3568 | 0.0121 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0081 | 0.3568 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 0.2551 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0137 | 0.8044 | 0.7673 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0154 | 0.9375 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2946 | 0.1605 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0137 | 0.8044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0137 | 0.8044 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0137 | 0.8044 | 0.7735 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0053 | 0.1366 | 0.3828 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0137 | 0.8044 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0154 | 0.9375 | 0.9028 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0093 | 0.452 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0093 | 0.452 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3605 | 0.239 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0162 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.3568 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3568 | 0.2346 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0154 | 0.9375 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4531 | 0.3492 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.008 | 0.3513 | 0.9604 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0162 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 0.0121 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0154 | 0.9375 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.008 | 0.3513 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0137 | 0.8044 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0137 | 0.8044 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.013 | 0.7478 | 0.5 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0154 | 0.9375 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.3568 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0081 | 0.3568 | 0.0121 |
Schistosoma mansoni | DNA topoisomerase II | 0.0137 | 0.8044 | 0.6959 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0137 | 0.8044 | 0.7735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.