Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Matrix metalloproteinase 9 | Starlite/ChEMBL | No references |
Rattus norvegicus | Matrix metalloproteinase 8 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | BCL7-like protein homolog | Matrix metalloproteinase 8 | 466 aa | 494 aa | 30.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | Matrix metalloproteinase 8 | 466 aa | 484 aa | 31.4 % |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | Matrix metalloproteinase 8 | 466 aa | 484 aa | 31.4 % |
Drosophila melanogaster | Matrix metalloproteinase 1 | Matrix metalloproteinase 8 | 466 aa | 449 aa | 37.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0062 | 0 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0097 | 0.3607 | 1 |
Brugia malayi | Matrixin family protein | 0.0106 | 0.4509 | 1 |
Plasmodium vivax | transporter, putative | 0.0091 | 0.2999 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0091 | 0.2999 | 0.5 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0091 | 0.2999 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0159 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0106 | 0.4509 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0091 | 0.2999 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0097 | 0.3607 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.6 uM | Compound was tested for its inhibitory activity against Matrix metalloproteinase-8 (MMP-8) in adjuvant arthritic rat model of rheumatoid arthritis | ChEMBL. | No reference |
IC50 (binding) | = 2.6 uM | Compound was tested for its inhibitory activity against Matrix metalloproteinase-8 (MMP-8) in adjuvant arthritic rat model of rheumatoid arthritis | ChEMBL. | No reference |
IC50 (binding) | = 4.6 uM | Compound was tested for its inhibitory activity against Matrix Matrix metalloproteinase-9 in adjuvant arthritic rat model of rheumatoid arthritis | ChEMBL. | No reference |
IC50 (binding) | = 4.6 uM | Compound was tested for its inhibitory activity against Matrix Matrix metalloproteinase-9 in adjuvant arthritic rat model of rheumatoid arthritis | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Compound was tested for its inhibitory activity against Matrix metalloproteinase-3 (MMP-3) in adjuvant arthritic rat model of rheumatoid arthritis | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Compound was tested for its inhibitory activity against Matrix metalloproteinase-3 (MMP-3) in adjuvant arthritic rat model of rheumatoid arthritis | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.