Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | No references |
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor 2 | 0.1571 | 0.2592 | 0.2592 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1543 | 0.2445 | 0.2445 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1717 | 0.3347 | 0.3347 |
Echinococcus granulosus | glutamate receptor 2 | 0.1571 | 0.2592 | 0.2592 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.1314 | 0.1263 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1717 | 0.3347 | 0.3347 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1312 | 0.125 | 0.125 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.1571 | 0.2592 | 0.2592 |
Echinococcus granulosus | glutamate receptor NMDA | 0.146 | 0.2018 | 0.2018 |
Brugia malayi | Glutamate receptor 1 precursor | 0.1314 | 0.1263 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1312 | 0.125 | 0.125 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1312 | 0.125 | 0.125 |
Brugia malayi | Glutamate receptor 2 precursor | 0.1314 | 0.1263 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.146 | 0.2018 | 0.2018 |
Schistosoma mansoni | glutamate receptor NMDA | 0.2772 | 0.8805 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.1571 | 0.2592 | 0.2592 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1312 | 0.125 | 0.125 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1312 | 0.125 | 0.125 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.3003 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.1314 | 0.1263 | 0.1263 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1312 | 0.125 | 0.125 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -6.3 | Inhibition of [125 I]-iodosulpride binding to human Dopamine receptor D3 expressed in CHO cell membranes | ChEMBL. | No reference |
Ki (binding) | = -4.9 | Inhibition of [125 I]-iodosulpride binding to human Dopamine receptor D2 expressed in CHO cell membranes | ChEMBL. | No reference |
Log Ki (binding) | = 4.9 | Inhibition of [125 I]-iodosulpride binding to human Dopamine receptor D2 expressed in CHO cell membranes | ChEMBL. | No reference |
Log Ki (binding) | = 6.3 | Inhibition of [125 I]-iodosulpride binding to human Dopamine receptor D3 expressed in CHO cell membranes | ChEMBL. | No reference |
Selectivity (binding) | = 25 | Selectivity was determined using ratio of Ki (nM) value at dopamine D2 and D3 receptors | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.