Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ingi protein (ORF1) | 0.027 | 0.2621 | 0.0309 |
Leishmania major | ribonuclease H1, putative | 0.0249 | 0.2386 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0021 | 0.0021 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0021 | 0.5 |
Echinococcus multilocularis | ribonuclease H1 | 0.0249 | 0.2386 | 0.4043 |
Brugia malayi | RNase H family protein | 0.0249 | 0.2386 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0221 | 0.1095 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0249 | 0.2386 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0249 | 0.2386 | 0.2386 |
Toxoplasma gondii | ribonuclease HI protein | 0.0249 | 0.2386 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0188 | 0.0932 |
Trypanosoma brucei | ingi protein (ORF1) | 0.027 | 0.2621 | 0.0309 |
Trypanosoma brucei | RNA helicase, putative | 0.0934 | 1 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0249 | 0.2386 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0249 | 0.2386 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0123 | 0.0979 | 0.1638 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0177 | 0.0877 |
Brugia malayi | Pre-SET motif family protein | 0.0216 | 0.2021 | 0.8469 |
Brugia malayi | RNase H family protein | 0.0249 | 0.2386 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0249 | 0.2386 | 0.2386 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0249 | 0.2386 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0021 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0249 | 0.2386 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0188 | 0.0188 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.027 | 0.2621 | 0.0309 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0021 | 0.0021 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0021 | 0.0089 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0216 | 0.2021 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0563 | 0.5869 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0177 | 0.0877 |
Giardia lamblia | Ribonuclease H | 0.0249 | 0.2386 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0563 | 0.5869 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0123 | 0.0979 | 0.1638 |
Echinococcus multilocularis | tumor protein p63 | 0.0351 | 0.3519 | 0.5981 |
Brugia malayi | RNase H family protein | 0.0249 | 0.2386 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0249 | 0.2386 | 0.2386 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.0569 | 0.0569 |
Onchocerca volvulus | 0.0246 | 0.2353 | 0.9848 | |
Schistosoma mansoni | lipoxygenase | 0.0123 | 0.0979 | 0.0979 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0221 | 0.0927 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0177 | 0.0743 |
Trypanosoma brucei | unspecified product | 0.027 | 0.2621 | 0.0309 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0021 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0249 | 0.2386 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0177 | 0.0743 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0021 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0351 | 0.3519 | 0.5981 |
Trypanosoma brucei | hypothetical protein, conserved | 0.027 | 0.2621 | 0.0309 |
Echinococcus granulosus | ribonuclease H1 | 0.0249 | 0.2386 | 0.4043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Score (functional) | = 159 | Inhibition of the 6-OHDA-induced Hypokinesia in rat, at 50 mg/Kg sc, expressed as cumulative ambulation score | ChEMBL. | 6429333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.