Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Echinococcus multilocularis | neutral sphingomyelinase | 0.0133 | 1 | 1 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | neutral sphingomyelinase | 0.0133 | 1 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0092 | 0 | 0.5 |
Echinococcus granulosus | neutral sphingomyelinase | 0.0133 | 1 | 1 |
Onchocerca volvulus | Putative neutral sphingomyelinase | 0.0133 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 430 uM | Tested for its inhibitory activity against the enzyme chorismate mutase (CM) in E. coli T-protein | ChEMBL. | 11958996 |
Ki (binding) | = 590 uM | Tested for its inhibitory activity against the enzyme prephenate dehyderogenase (PDH) in E. coli T-protein | ChEMBL. | 11958996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.