Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0158 | 0.2928 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0107 | 0.1515 | 0.4544 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0158 | 0.2928 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0158 | 0.2928 | 0.0634 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0218 | 0.4613 | 0.3651 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0185 | 0.3691 | 0.3691 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0191 | 0.3843 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2734 | 0.2838 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0411 | 1 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0158 | 0.2928 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0158 | 0.2928 | 0.0266 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0191 | 0.3849 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2734 | 0.2838 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0218 | 0.4613 | 0.2865 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2734 | 0.1035 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0411 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0218 | 0.4613 | 0.4613 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0411 | 1 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0411 | 1 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0191 | 0.3849 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0218 | 0.4613 | 0.2586 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0191 | 0.3849 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0191 | 0.3849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.085 | 0.1978 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0158 | 0.2928 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0411 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0148 | 0.2649 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0158 | 0.2928 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0218 | 0.4613 | 0.3651 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0141 | 0.2449 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0158 | 0.2928 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0141 | 0.2449 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0411 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2734 | 0.2838 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0151 | 0.2734 | 0.0377 |
Schistosoma mansoni | DNA topoisomerase II | 0.0158 | 0.2928 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0411 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0141 | 0.2449 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0158 | 0.2928 | 0.1274 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0158 | 0.2928 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0158 | 0.2928 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.085 | 0.1978 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 uM | Neuronal voltage-dependent calcium channel (VDCC) inhibitory activity determined in rat cortical synaptosomes | ChEMBL. | 12617921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.