Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | No references |
Homo sapiens | tachykinin receptor 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | type A flavoprotein, putative | 0.0156 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0409 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0409 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0206 | 0.1964 | 0.0151 |
Treponema pallidum | flavodoxin | 0.0156 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0409 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0409 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0409 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0409 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0409 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0362 | 0.8159 | 0.8159 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0253 | 0.3805 | 0.3805 |
Giardia lamblia | Hypothetical protein | 0.0362 | 0.8159 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0409 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0409 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0409 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0156 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0362 | 0.8159 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0156 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0409 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0203 | 0.1841 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0409 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0409 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0362 | 0.8159 | 0.8159 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0409 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0409 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0253 | 0.3805 | 0.3805 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0409 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0409 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0409 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0156 | 0 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0253 | 0.3805 | 0.2407 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0409 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0409 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0156 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0203 | 0.1841 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0362 | 0.8159 | 0.8159 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0409 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0409 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0253 | 0.3805 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.8 nM | Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA | ChEMBL. | No reference |
IC50 (binding) | = 11.8 nM | Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA | ChEMBL. | No reference |
IC50 (binding) | = 634 nM | Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP | ChEMBL. | No reference |
IC50 (binding) | = 634 nM | Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.