Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0072 | 0.1488 | 0.1488 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0148 | 0.7031 | 0.7031 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0148 | 0.7031 | 0.7031 |
Trypanosoma brucei | prolyl endopeptidase | 0.0148 | 0.7031 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0067 | 0.1084 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0148 | 0.7031 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0148 | 0.7031 | 0.7031 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0188 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0148 | 0.7031 | 0.7031 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0188 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0072 | 0.1488 | 0.1488 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0148 | 0.7031 | 0.7031 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0067 | 0.1084 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0072 | 0.1488 | 0.068 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0072 | 0.1488 | 0.068 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0072 | 0.1488 | 0.1488 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0188 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0188 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0148 | 0.7031 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0072 | 0.1488 | 0.068 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0072 | 0.1488 | 0.068 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0072 | 0.1488 | 0.1488 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0148 | 0.7031 | 0.7031 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0148 | 0.7031 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.7031 | 0.7031 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0072 | 0.1488 | 0.068 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0188 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.012 | 0.4979 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 67 % | Percent plasma glucose concentration of drug treated mice (ob/ob) relative to vehicle control animals | ChEMBL. | 1548684 |
Activity (functional) | = 67 % | Percent plasma glucose concentration of drug treated mice (ob/ob) relative to vehicle control animals | ChEMBL. | 1548684 |
Body weight (functional) | = 29.9 g | Effect on the mean body weight of mice on day 1 (pre) of swiss CD-1 mice (charles river), in groups of six dosed orally once per day for 4 days with 50 mg/kg of compound | ChEMBL. | 1548684 |
Body weight (functional) | = 29.9 g | Effect on the mean body weight of mice on day 1 (pre) of swiss CD-1 mice (charles river), in groups of six dosed orally once per day for 4 days with 50 mg/kg of compound | ChEMBL. | 1548684 |
Body weight (functional) | = 31.1 g | Effect on the mean body weight of mice on day 5 (post) of swiss CD-1 mice (charles river), in groups of six dosed orally once per day for 4 days with 50 mg/kg of compound | ChEMBL. | 1548684 |
Body weight (functional) | = 31.1 g | Effect on the mean body weight of mice on day 5 (post) of swiss CD-1 mice (charles river), in groups of six dosed orally once per day for 4 days with 50 mg/kg of compound | ChEMBL. | 1548684 |
Heart weight (functional) | = 41 mg 10g-1 | Effect on the mean heart weight of mice on day 1 (pre) of swiss CD-1 mice (charles river), in groups of six dosed orally once per day for 4 days with 50 mg/kg of compound; expressed as mg/10 g body weight | ChEMBL. | 1548684 |
Heart weight (functional) | = 41 mg 10g-1 | Effect on the mean heart weight of mice on day 1 (pre) of swiss CD-1 mice (charles river), in groups of six dosed orally once per day for 4 days with 50 mg/kg of compound; expressed as mg/10 g body weight | ChEMBL. | 1548684 |
Liver weight (functional) | = 0.942 mg 10g-1 | Effect on the mean liver weight of mice on day 1 (pre) of swiss CD-1 mice (charles river), in groups of six dosed orally once per day for 4 days with 50 mg/kg of compound; expressed as mg/10 g body weight | ChEMBL. | 1548684 |
Liver weight (functional) | = 0.942 mg 10g-1 | Effect on the mean liver weight of mice on day 1 (pre) of swiss CD-1 mice (charles river), in groups of six dosed orally once per day for 4 days with 50 mg/kg of compound; expressed as mg/10 g body weight | ChEMBL. | 1548684 |
Plasma glucose (functional) | = 119 mg dl-1 | Activity of perorally administered compound at a dose of 20 mg/kg for 4 days against plasma glucose in obese mice | ChEMBL. | 2642552 |
Plasma glucose (functional) | = 119 mg dl-1 | Activity of perorally administered compound at a dose of 20 mg/kg for 4 days against plasma glucose in obese mice | ChEMBL. | 2642552 |
Plasma insulin (functional) | = 204 ml | Activity of perorally administered compound at a dose of 20 mg/kg for 4 days against plasma insulin in obese mice | ChEMBL. | 2642552 |
Plasma insulin (functional) | = 204 ml | Activity of perorally administered compound at a dose of 20 mg/kg for 4 days against plasma insulin in obese mice | ChEMBL. | 2642552 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.