Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0677 | 0.5 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0677 | 0.5 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0677 | 0.5 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0677 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0677 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0677 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0677 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0677 | 0.5 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0677 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0677 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0677 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0677 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0677 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0677 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0677 | 0.5 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0677 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0677 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0677 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0677 | 0.5 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0677 | 0.5 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0677 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0677 | 0.5 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0677 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Affinity (binding) | = 0.042 | Relative binding affinity (RBA) for human Estrogen receptor beta compared to estradiol | ChEMBL. | 11959000 |
Affinity (binding) | = 0.56 | Relative binding affinity (RBA) for human Estrogen receptor alpha compared to estradiol | ChEMBL. | 11959000 |
Affinity (binding) | = 0.042 | Relative binding affinity (RBA) for human Estrogen receptor beta compared to estradiol | ChEMBL. | 11959000 |
Affinity (binding) | = 0.56 | Relative binding affinity (RBA) for human Estrogen receptor alpha compared to estradiol | ChEMBL. | 11959000 |
Ratio (binding) | = 13 | Selectivity ratio as relative binding affinity for estrogen receptor alpha and beta | ChEMBL. | 11959000 |
Ratio (binding) | = 13 | Selectivity ratio as relative binding affinity for estrogen receptor alpha and beta | ChEMBL. | 11959000 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.