Detailed information for compound 305881

Basic information

Technical information
  • TDR Targets ID: 305881
  • Name: (2R,3R)-2-[(3,4-dimethoxyphenyl)methyl]-3-[(4 -hydroxy-3-methoxyphenyl)methyl]butane-1,4-di ol
  • MW: 376.443 | Formula: C21H28O6
  • H donors: 3 H acceptors: 3 LogP: 2.84 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]([C@@H](Cc1ccc(c(c1)OC)O)CO)Cc1ccc(c(c1)OC)OC
  • InChi: 1S/C21H28O6/c1-25-19-7-5-15(11-21(19)27-3)9-17(13-23)16(12-22)8-14-4-6-18(24)20(10-14)26-2/h4-7,10-11,16-17,22-24H,8-9,12-13H2,1-3H3/t16-,17-/m0/s1
  • InChiKey: QOOLUDONRDSQAX-IRXDYDNUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R)-2-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxy-phenyl)methyl]butane-1,4-diol
  • (2R,3R)-2-vanillyl-3-veratryl-butane-1,4-diol
  • (2R,3R)-2-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxy-benzyl)butane-1,4-diol
  • AIDS030819
  • (2R,3R)-2-(4'-Hydroxy-3'-methoxybenzyl)-3-(3"",4""-dimethoxybenzyl)-1,4-butanediol
  • AIDS-030819

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0494 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Echinococcus granulosus somatostatin receptor 0.0358 0.5444 0.5444
Schistosoma mansoni amine GPCR 0.0358 0.5444 0.5302
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0191 0.0191
Echinococcus granulosus alpha 1A adrenergic receptor 0.0358 0.5444 0.5444
Echinococcus granulosus tm gpcr rhodopsin 0.0358 0.5444 0.5444
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1305 0.1136
Echinococcus granulosus neuropeptide s receptor 0.0358 0.5444 0.5444
Echinococcus granulosus neuropeptide receptor A26 0.0358 0.5444 0.5444
Echinococcus multilocularis Mastin 0.0152 0.1927 0.1927
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.1927 0.1675
Brugia malayi Serotonin receptor 0.0358 0.5444 0.5357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0358 0.5444 0.5444
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0302 0.0302
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Onchocerca volvulus 0.0358 0.5444 0.5049
Onchocerca volvulus 0.0358 0.5444 0.5049
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0152 0.1927 0.1772
Brugia malayi neuropeptide F receptor 0.0358 0.5444 0.5357
Schistosoma mansoni amine GPCR 0.0358 0.5444 0.5302
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0799 0.0623
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni biogenic amine (5HT) receptor 0.0358 0.5444 0.5302
Schistosoma mansoni hypothetical protein 0.0152 0.1927 0.1675
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni neuropeptide F-like receptor 0.0358 0.5444 0.5302
Echinococcus multilocularis neuropeptides capa receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis neuropeptide receptor 0.0358 0.5444 0.5444
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1305 0.1136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Schistosoma mansoni hypothetical protein 0.0358 0.5444 0.5302
Brugia malayi GnHR receptor homolog 0.0358 0.5444 0.5357
Schistosoma mansoni hypothetical protein 0.0358 0.5444 0.5302
Mycobacterium ulcerans hypothetical protein 0.0152 0.1927 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0358 0.5444 0.5302
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0624 1 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0152 0.1927 0.1927
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0358 0.5444 0.5444
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0624 1 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0358 0.5444 0.5302
Echinococcus multilocularis fmrfamide receptor 0.0358 0.5444 0.5444
Brugia malayi Dopamine receptor protein 1 0.0358 0.5444 0.5357
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0624 1 1
Echinococcus multilocularis glycoprotein Antigen 5 0.0152 0.1927 0.1927
Echinococcus granulosus tm gpcr rhodopsin 0.0358 0.5444 0.5444
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0494 0.031
Plasmodium falciparum eukaryotic initiation factor 4A 0.0624 1 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus dro:myosuppressin receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis g protein coupled receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0624 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0624 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.1927 0.1772
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0358 0.5444 0.5302
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0358 0.5444 0.5444
Onchocerca volvulus 0.0358 0.5444 0.5049
Brugia malayi Trypsin-like protease protein 5 0.0152 0.1927 0.1772
Onchocerca volvulus 0.0152 0.1927 0.1226
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0358 0.5444 0.5357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Echinococcus granulosus biogenic amine 5HT receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0152 0.1927 0.1772
Brugia malayi AKH receptor 0.0358 0.5444 0.5357
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0358 0.5444 0.5049
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus biogenic amine 5HT receptor 0.0358 0.5444 0.5444
Echinococcus granulosus neuropeptides capa receptor 0.0358 0.5444 0.5444
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0358 0.5444 0.5444
Brugia malayi Tachykinin-like peptides receptor 99D 0.0358 0.5444 0.5357
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0358 0.5444 0.5302
Echinococcus multilocularis G-protein coupled receptor, putative 0.0358 0.5444 0.5444
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0191 0.0191
Onchocerca volvulus 0.0358 0.5444 0.5049
Onchocerca volvulus 0.0152 0.1927 0.1226
Brugia malayi Melatonin receptor type 1A 0.0358 0.5444 0.5357
Onchocerca volvulus 0.0358 0.5444 0.5049
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Onchocerca volvulus 0.0358 0.5444 0.5049
Brugia malayi hypothetical protein 0.0152 0.1927 0.1772
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus multilocularis transmembrane protease serine 3 0.0152 0.1927 0.1927
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.1927 0.1675
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni neuropeptide receptor 0.0358 0.5444 0.5302
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.1927 0.1675
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0358 0.5444 0.5357
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.1927 0.1675
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0358 0.5444 0.5357
Echinococcus multilocularis g protein coupled receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) neuropeptide F receptor 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Echinococcus multilocularis serotonin receptor 0.0358 0.5444 0.5444
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) melatonin receptor type 1A 0.0358 0.5444 0.5357
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1527 0.1362
Echinococcus granulosus peptide allatostatin:somatostatin 0.0358 0.5444 0.5444
Echinococcus granulosus neuropeptide receptor 0.0358 0.5444 0.5444
Brugia malayi G protein-coupled receptor F59B2.13 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Onchocerca volvulus 0.0358 0.5444 0.5049
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Loa Loa (eye worm) TYRA-2 protein 0.0358 0.5444 0.5357
Brugia malayi G protein-coupled receptor 0.0358 0.5444 0.5357
Brugia malayi putative neuropeptide receptor 0.0358 0.5444 0.5357
Echinococcus multilocularis g protein coupled receptor 0.0358 0.5444 0.5444
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1527 0.1362
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Schistosoma mansoni adenoreceptor 0.0358 0.5444 0.5302
Echinococcus multilocularis sex peptide receptor 0.0358 0.5444 0.5444
Echinococcus granulosus sex peptide receptor 0.0358 0.5444 0.5444
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1527 1
Loa Loa (eye worm) G-protein coupled receptor 0.0358 0.5444 0.5357
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0358 0.5444 0.5444
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0358 0.5444 0.5357
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0358 0.5444 0.5302
Schistosoma mansoni neuropeptide receptor 0.0358 0.5444 0.5302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0358 0.5444 0.5302
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Brugia malayi glutathione reductase 0.0051 0.0191 0.0003
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0358 0.5444 0.5302
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus multilocularis dro:myosuppressin receptor 0.0358 0.5444 0.5444
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0799 0.0799
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Onchocerca volvulus 0.0358 0.5444 0.5049
Echinococcus granulosus g protein coupled receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis G protein coupled receptor 139 0.0358 0.5444 0.5444
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0624 1 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0358 0.5444 0.5444
Schistosoma mansoni neuropeptide receptor 0.0358 0.5444 0.5302
Onchocerca volvulus 0.0358 0.5444 0.5049
Loa Loa (eye worm) neuropeptide F receptor 0.0358 0.5444 0.5357
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis neuropeptide Y receptor 0.0358 0.5444 0.5444
Brugia malayi Trypsin family protein 0.0152 0.1927 0.1772
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Brugia malayi neuropeptide F receptor 0.0358 0.5444 0.5357
Onchocerca volvulus 0.0358 0.5444 0.5049
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0799 0.0799
Onchocerca volvulus 0.0358 0.5444 0.5049
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0624 1 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.1927 0.1675
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0358 0.5444 0.5444
Echinococcus multilocularis neuropeptide receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0358 0.5444 0.5444
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0152 0.1927 0.1675
Loa Loa (eye worm) trypsin family protein 0.0152 0.1927 0.1772
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0624 1 1
Echinococcus multilocularis orexin receptor type 2 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0624 1 0.5
Schistosoma mansoni biogenic amine receptor 0.0358 0.5444 0.5302
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0358 0.5444 0.5302
Schistosoma mansoni hypothetical protein 0.0152 0.1927 0.1675
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0358 0.5444 0.5357
Echinococcus granulosus transmembrane protease serine 3 0.0152 0.1927 0.1927
Echinococcus granulosus neuropeptides capa receptor 0.0358 0.5444 0.5444
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0358 0.5444 0.5302
Echinococcus multilocularis neuropeptide receptor A26 0.0358 0.5444 0.5444
Onchocerca volvulus 0.0152 0.1927 0.1226
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0494 0.031
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.1927 0.1675
Brugia malayi Trypsin family protein 0.0152 0.1927 0.1772
Schistosoma mansoni alpha-1 adrenergic receptor 0.0358 0.5444 0.5302
Schistosoma mansoni myosin xvIII 0.0358 0.5444 0.5302
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Loa Loa (eye worm) G-protein coupled receptor 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0624 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0358 0.5444 0.5302
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1305 0.1136
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0152 0.1927 0.1772
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0624 1 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0624 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0358 0.5444 0.5444
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0358 0.5444 0.5302
Treponema pallidum ATP-dependent RNA helicase 0.0624 1 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0358 0.5444 0.5444
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0624 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0358 0.5444 0.5302
Schistosoma mansoni amine GPCR 0.0358 0.5444 0.5302
Echinococcus granulosus tachykinin peptides receptor 99D 0.0358 0.5444 0.5444
Echinococcus granulosus g protein coupled receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis g-protein coupled receptor 0.0358 0.5444 0.5444
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0624 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0799 0.0623
Brugia malayi Trypsin family protein 0.0152 0.1927 0.1772
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Echinococcus multilocularis allatostatin A receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis somatostatin receptor 0.0358 0.5444 0.5444
Echinococcus granulosus eukaryotic initiation factor 4A 0.0624 1 1
Echinococcus granulosus Mastin 0.0152 0.1927 0.1927
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0358 0.5444 0.5302
Schistosoma mansoni neuropeptide receptor 0.0358 0.5444 0.5302
Schistosoma mansoni amine GPCR 0.0358 0.5444 0.5302
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0494 0.0312
Echinococcus granulosus g-protein coupled receptor 0.0358 0.5444 0.5444
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0358 0.5444 0.5444
Brugia malayi Trypsin family protein 0.0152 0.1927 0.1772
Echinococcus granulosus serotonin receptor 0.0358 0.5444 0.5444
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0358 0.5444 0.5302
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0152 0.1927 0.1927
Brugia malayi larval opioid receptor 0.0358 0.5444 0.5357
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Brugia malayi follicle stimulating hormone receptor 0.0358 0.5444 0.5357
Onchocerca volvulus 0.0358 0.5444 0.5049
Onchocerca volvulus 0.0358 0.5444 0.5049
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0494 0.0312
Echinococcus granulosus enteropeptidase 0.0152 0.1927 0.1927
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus allatostatin A receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni hypothetical protein 0.0358 0.5444 0.5302
Echinococcus multilocularis neuropeptide s receptor 0.0358 0.5444 0.5444
Leishmania major eukaryotic initiation factor 4a, putative 0.0624 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0358 0.5444 0.5444
Onchocerca volvulus 0.0152 0.1927 0.1226
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0624 1 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Brugia malayi Dopamine receptor 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus neuropeptide Y receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0152 0.1927 0.1772
Schistosoma mansoni hypothetical protein 0.0358 0.5444 0.5302
Plasmodium vivax RNA helicase-1, putative 0.0624 1 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0152 0.1927 0.1927
Onchocerca volvulus 0.0152 0.1927 0.1226
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0358 0.5444 0.5357
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Onchocerca volvulus 0.0358 0.5444 0.5049
Echinococcus granulosus g protein coupled receptor 0.0358 0.5444 0.5444
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Echinococcus granulosus neuropeptide receptor 0.0358 0.5444 0.5444
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0358 0.5444 0.5444
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0152 0.1927 0.1927
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0358 0.5444 0.5444
Brugia malayi ORL1-like opioid receptor 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.1927 0.1675
Brugia malayi sulfakinin receptor protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1527 0.1362
Schistosoma mansoni biogenic amine receptor 0.0358 0.5444 0.5302
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0358 0.5444 0.5444
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Onchocerca volvulus 0.0358 0.5444 0.5049
Echinococcus granulosus orexin receptor type 2 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni neuropeptide F-like receptor 0.0358 0.5444 0.5302
Brugia malayi Thioredoxin reductase 0.0051 0.0191 0.0003
Schistosoma mansoni histamine h1 receptor 0.0358 0.5444 0.5302
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus glycoprotein Antigen 5 0.0152 0.1927 0.1927
Loa Loa (eye worm) glutathione reductase 0.0051 0.0191 0.0003
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0624 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Onchocerca volvulus 0.0152 0.1927 0.1226
Schistosoma mansoni biogenic amine receptor 0.0358 0.5444 0.5302
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0302 0.0302
Brugia malayi putative neuropeptide receptor NPR1 0.0358 0.5444 0.5357
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0624 1 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0624 1 1
Schistosoma mansoni opsin-like receptor 0.0358 0.5444 0.5302
Schistosoma mansoni neuropeptide f receptor 76f 0.0358 0.5444 0.5302
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Brugia malayi Dopamine receptor protein 2 0.0358 0.5444 0.5357
Schistosoma mansoni growth hormone secretagogue receptor 0.0358 0.5444 0.5302
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Brugia malayi G-protein coupled receptor 0.0358 0.5444 0.5357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus 7tm_1 domain containing protein 0.0358 0.5444 0.5444
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Schistosoma mansoni amine GPCR 0.0358 0.5444 0.5302
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus tm gpcr rhodopsin 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1305 0.1136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Echinococcus multilocularis enteropeptidase 0.0152 0.1927 0.1927
Onchocerca volvulus Neuropeptide F receptor homolog 0.0358 0.5444 0.5049
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1305 0.1136
Echinococcus multilocularis serotonin receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0152 0.1927 0.1772
Echinococcus multilocularis neuropeptides capa receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Brugia malayi RE15519p 0.0358 0.5444 0.5357
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0494 0.0494
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0494 0.031
Onchocerca volvulus 0.0358 0.5444 0.5049
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0799 0.0512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0358 0.5444 0.5357
Echinococcus multilocularis fmrfamide receptor 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0358 0.5444 0.5357
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0494 0.0494
Echinococcus granulosus G protein coupled receptor 139 0.0358 0.5444 0.5444
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Echinococcus granulosus rhodopsin orphan GPCR 0.0358 0.5444 0.5444
Brugia malayi G-protein coupled receptor 0.0358 0.5444 0.5357
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0494 0.031
Echinococcus multilocularis neuropeptide Y receptor 0.0358 0.5444 0.5444
Mycobacterium tuberculosis Probable reductase 0.0116 0.1305 0.1136
Brugia malayi Serotonin receptor 0.0358 0.5444 0.5357
Onchocerca volvulus 0.0358 0.5444 0.5049
Echinococcus granulosus neuropeptide Y receptor 0.0358 0.5444 0.5444
Echinococcus granulosus fmrfamide receptor 0.0358 0.5444 0.5444
Echinococcus multilocularis neuropeptide FF receptor 2 0.0358 0.5444 0.5444
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0152 0.1927 0.1772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0358 0.5444 0.5302
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357
Schistosoma mansoni cercarial elastase (S01 family) 0.0152 0.1927 0.1675
Schistosoma mansoni opsin-like receptor 0.0358 0.5444 0.5302
Schistosoma mansoni opsin-like receptor 0.0358 0.5444 0.5302
Brugia malayi hypothetical protein 0.0358 0.5444 0.5357
Loa Loa (eye worm) hypothetical protein 0.0152 0.1927 0.1772
Echinococcus granulosus hypothetical protein 0.0358 0.5444 0.5444
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0191 0.0003
Loa Loa (eye worm) hypothetical protein 0.0358 0.5444 0.5357

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 5 % Inhibitory activity against 3'-processing by HIV-1 Integrase at 100 microM ChEMBL. 8568830
Inhibition (binding) < 5 % Inhibitory activity against strand transfer by HIV-1 Integrase at 100 microM ChEMBL. 8568830
Inhibition (binding) < 5 % Inhibitory activity against 3'-processing by HIV-1 Integrase at 100 microM ChEMBL. 8568830
Inhibition (binding) < 5 % Inhibitory activity against strand transfer by HIV-1 Integrase at 100 microM ChEMBL. 8568830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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