Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta p (functional) | = -25 % | Antihypertensive activity on spontaneously hypertensive rats when administered orally at a dose 50 mg/kg. | ChEMBL. | 2989524 |
Ki (binding) | = 73.5 nM | Ability to displace [3H]-prazosin from postsynaptic alpha-1 adrenergic receptor of rat in vitro. | ChEMBL. | 2989524 |
Ki (binding) | = 73.5 nM | Ability to displace [3H]-prazosin from postsynaptic alpha-1 adrenergic receptor of rat in vitro. | ChEMBL. | 2989524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.