Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0225 | 0.0453 | 0.0153 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0225 | 0.0453 | 0.0453 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0225 | 0.0453 | 0.0453 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0388 | 0.1026 | 0.1026 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0388 | 0.1026 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0225 | 0.0453 | 0.0453 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.1164 | 0.3756 | 0.4342 |
Entamoeba histolytica | hypothetical protein | 0.0225 | 0.0453 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0612 | 0.1816 | 0.1427 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0225 | 0.0453 | 0.0453 |
Schistosoma mansoni | tyrosine kinase | 0.0225 | 0.0453 | 0.0153 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.2001 | 0.6697 | 0.6697 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0388 | 0.1026 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0225 | 0.0453 | 0.0453 |
Leishmania major | extracellular receptor, putative | 0.0225 | 0.0453 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0225 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | glutamate receptor | 0.094 | 0.2967 | 0.2633 |
Echinococcus multilocularis | tyrosine kinase | 0.0225 | 0.0453 | 0.0453 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.2164 | 0.727 | 0.8962 |
Loa Loa (eye worm) | glutamate receptor | 0.2389 | 0.806 | 0.7968 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.2001 | 0.6697 | 0.6697 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.2941 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0225 | 0.0453 | 0.0453 |
Schistosoma mansoni | tyrosine kinase | 0.0225 | 0.0453 | 0.0153 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0612 | 0.1816 | 0.1427 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0225 | 0.0453 | 0.0453 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0612 | 0.1816 | 0.1792 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.2001 | 0.6697 | 0.7174 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0612 | 0.1816 | 0.1427 |
Schistosoma mansoni | protein kinase | 0.0225 | 0.0453 | 0.0153 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0225 | 0.0453 | 0.0453 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0388 | 0.1026 | 0.1026 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0225 | 0.0453 | 0.0453 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.1164 | 0.3756 | 0.3867 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0388 | 0.1026 | 0.0754 |
Echinococcus granulosus | glutamate receptor 2 | 0.0225 | 0.0453 | 0.0453 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0225 | 0.0453 | 0.0453 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.2389 | 0.806 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0225 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0388 | 0.1026 | 0.0601 |
Echinococcus granulosus | tyrosine kinase | 0.0225 | 0.0453 | 0.0453 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0225 | 0.0453 | 0.0453 |
Schistosoma mansoni | hypothetical protein | 0.0388 | 0.1026 | 0.0798 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0225 | 0.0453 | 0.0453 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.2716 | 0.9211 | 1 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0225 | 0.0453 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0225 | 0.0453 | 0.0453 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0225 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.2941 | 1 | 1 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0225 | 0.0453 | 0.0453 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Inhibitory activity was tested against human collagenase (MMP-1) | ChEMBL. | No reference |
IC50 (binding) | = 1.1 uM | Inhibitory activity was tested against human collagenase (MMP-1) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.