Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0412 | 0.3256 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0412 | 0.3256 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1055 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1055 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1055 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0412 | 0.3256 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1055 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1055 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0412 | 0.3256 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.1055 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1055 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1055 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1055 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0412 | 0.3256 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1055 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0412 | 0.3256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1055 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1055 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0412 | 0.3256 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1055 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0412 | 0.3256 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0412 | 0.3256 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0412 | 0.3256 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0412 | 0.3256 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1055 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 27 ug ml-1 | Inhibition the IL-6 secretion stimulated at a concentration of 10 ng/ml in osteoblastic MC3T3-E 1 cells. | ChEMBL. | 10230619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.