TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 256.298 | Formula: C12H20N2O4
H donors: 2 H acceptors: 3 LogP: -3.33 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C1[C@@H]2C=C[C@H](C1C(=O)N(C)C)O2.CNC
InChi: 1S/C10H13NO4.C2H7N/c1-11(2)9(12)7-5-3-4-6(15-5)8(7)10(13)14;1-3-2/h3-8H,1-2H3,(H,13,14);3H,1-2H3/t5-,6+,7?,8?;/m1./s1
InChiKey: FLYJFIAXXQEDPR-USEPEDARSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein phosphatase, Mg2+/Mn2+ dependent, 1B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	protein phosphatase, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania major	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Echinococcus granulosus	protein phosphatase 2c	Get druggable targets OG5_126741	All targets in OG5_126741
Neospora caninum	hypothetical protein	Get druggable targets OG5_126741	All targets in OG5_126741
Theileria parva	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Schistosoma mansoni	protein phosphatase 2C	Get druggable targets OG5_126741	All targets in OG5_126741
Trypanosoma cruzi	protein phosphatase 2C-like, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania donovani	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Trypanosoma brucei	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania braziliensis	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania braziliensis	protein phosphatase 2C-like protein	Get druggable targets OG5_126741	All targets in OG5_126741
Trypanosoma congolense	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Echinococcus granulosus	protein phosphatase 2c	Get druggable targets OG5_126741	All targets in OG5_126741
Giardia lamblia	Phosphatase	Get druggable targets OG5_126741	All targets in OG5_126741
Schistosoma mansoni	protein phosphatase 2C	Get druggable targets OG5_126741	All targets in OG5_126741
Trypanosoma cruzi	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126741	All targets in OG5_126741
Trypanosoma congolense	protein phosphatase 2C-like, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126741	All targets in OG5_126741
Plasmodium vivax	protein phosphatase PPM2, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania braziliensis	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania mexicana	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Plasmodium yoelii	Protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Schistosoma japonicum	ko:K04461 protein phosphatase 1B (formerly 2C), putative	Get druggable targets OG5_126741	All targets in OG5_126741
Schistosoma japonicum	ko:K01090 protein phosphatase [EC3.1.3.16], putative	Get druggable targets OG5_126741	All targets in OG5_126741
Cryptosporidium parvum	PP2C like protein phosphatase	Get druggable targets OG5_126741	All targets in OG5_126741
Giardia lamblia	Ser/Thr phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Candida albicans	type 2C protein phosphatase similar to S. cerevisiae PTC2 (YER089C) involved in G1/S cell cycle transition	Get druggable targets OG5_126741	All targets in OG5_126741
Brugia malayi	probable protein phosphatase 2C	Get druggable targets OG5_126741	All targets in OG5_126741
Plasmodium knowlesi	protein phosphatase PPM2, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Toxoplasma gondii	protein phosphatase 2C domain-containing protein	Get druggable targets OG5_126741	All targets in OG5_126741
Trypanosoma brucei	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania infantum	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Candida albicans	type 2C protein phosphatase similar to S. cerevisiae PTC2 (YER089C) involved in G1/S cell cycle transition	Get druggable targets OG5_126741	All targets in OG5_126741
Brugia malayi	Protein phosphatase 2C containing protein	Get druggable targets OG5_126741	All targets in OG5_126741
Plasmodium berghei	protein phosphatase PPM2	Get druggable targets OG5_126741	All targets in OG5_126741
Trypanosoma brucei gambiense	protein phosphatase 2C-like, putative,protein phosphatase 2C homolog 2	Get druggable targets OG5_126741	All targets in OG5_126741
Echinococcus multilocularis	protein phosphatase 1b	Get druggable targets OG5_126741	All targets in OG5_126741
Echinococcus granulosus	protein phosphatase 1b	Get druggable targets OG5_126741	All targets in OG5_126741
Toxoplasma gondii	protein phosphatase 2C domain-containing protein	Get druggable targets OG5_126741	All targets in OG5_126741
Babesia bovis	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Loa Loa (eye worm)	protein phosphatase 2C containing protein	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania donovani	protein phosphatase 2C-like protein	Get druggable targets OG5_126741	All targets in OG5_126741
Brugia malayi	Protein phosphatase 2C containing protein	Get druggable targets OG5_126741	All targets in OG5_126741
Trypanosoma brucei gambiense	protein phosphatase 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Neospora caninum	hypothetical protein	Get druggable targets OG5_126741	All targets in OG5_126741
Echinococcus multilocularis	protein phosphatase 2C	Get druggable targets OG5_126741	All targets in OG5_126741
Echinococcus multilocularis	protein phosphatase 2C	Get druggable targets OG5_126741	All targets in OG5_126741
Schistosoma mansoni	protein phosphatase 2c gamma	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania major	protein phosphatase 2C-like protein	Get druggable targets OG5_126741	All targets in OG5_126741
Cryptosporidium hominis	Ppm1g-prov protein	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania infantum	protein phosphatase 2C-like protein	Get druggable targets OG5_126741	All targets in OG5_126741
Plasmodium falciparum	protein phosphatase PPM2	Get druggable targets OG5_126741	All targets in OG5_126741
Trichomonas vaginalis	protein phosphatase type 2C, putative	Get druggable targets OG5_126741	All targets in OG5_126741
Onchocerca volvulus	Putative protein phosphatase 2C	Get druggable targets OG5_126741	All targets in OG5_126741
Schistosoma japonicum	ko:K01090 protein phosphatase [EC3.1.3.16], putative	Get druggable targets OG5_126741	All targets in OG5_126741
Leishmania mexicana	protein phosphatase 2C-like protein	Get druggable targets OG5_126741	All targets in OG5_126741

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein phosphatase 2C, putative	protein phosphatase, Mg2+/Mn2+ dependent, 1B	380 aa	322 aa	33.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0097	0.7999	0.7999
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	biogenic amine 5HT receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	hypothetical protein	0.0097	0.7999	0.7999
Echinococcus multilocularis	neuropeptide s receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	serotonin receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	opsin-like receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	neuropeptide receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	neuropeptide receptor A26	0.0097	0.7999	0.7999
Echinococcus granulosus	biogenic amine 5HT receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	somatostatin receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Echinococcus granulosus	neuropeptides capa receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	G protein coupled receptor 139	0.0097	0.7999	0.7999
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	neuropeptides capa receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	hypothetical protein	0.0097	0.7999	0.7999
Echinococcus multilocularis	fmrfamide receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	neuropeptide receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	g protein coupled receptor	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Schistosoma mansoni	hypothetical protein	0.0097	0.7999	0.7999
Echinococcus granulosus	orexin receptor type 2	0.0097	0.7999	0.7999
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.7999	0.7999
Schistosoma mansoni	neuropeptide F-like receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0097	0.7999	0.7999
Echinococcus multilocularis	neuropeptide Y receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine receptor	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	neuropeptide receptor A26	0.0097	0.7999	0.7999
Echinococcus granulosus	fmrfamide receptor	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	adenoreceptor	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	protein phosphatase 2C	0.01	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.7999	0.7999
Echinococcus multilocularis	fmrfamide receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.7999	0.7999
Echinococcus multilocularis	protein phosphatase 1b	0.01	1	1
Echinococcus granulosus	neuropeptide receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	neuropeptide receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Echinococcus granulosus	g protein coupled receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0097	0.7999	0.7999
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.7999	0.7999
Schistosoma mansoni	neuropeptide F-like receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Echinococcus granulosus	neuropeptide Y receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	neuropeptide receptor	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.7999	0.7999
Echinococcus granulosus	dro:myosuppressin receptor	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0097	0.7999	0.7999
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Loa Loa (eye worm)	protein phosphatase 2C containing protein	0.01	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0097	0.7999	0.7999
Echinococcus granulosus	sex peptide receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	sex peptide receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	neuropeptide f receptor 76f	0.0097	0.7999	0.7999
Schistosoma mansoni	neuropeptide receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	opsin-like receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	neuropeptide receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0097	0.7999	0.7999
Schistosoma mansoni	amine GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0097	0.7999	0.7999
Schistosoma mansoni	amine GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	hypothetical protein	0.0097	0.7999	0.7999
Schistosoma mansoni	opsin-like receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	neuropeptide Y receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	G protein coupled receptor 139	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Echinococcus multilocularis	neuropeptide receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	hypothetical protein	0.0097	0.7999	0.7999
Echinococcus multilocularis	somatostatin receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	neuropeptide FF receptor 2	0.0097	0.7999	0.7999
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0097	0.7999	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	amine GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	histamine h1 receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0097	0.7999	0.7999
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0097	0.7999	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0097	0.7999	0.7999
Echinococcus multilocularis	orexin receptor type 2	0.0097	0.7999	0.7999
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	allatostatin A receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Echinococcus granulosus	protein phosphatase 1b	0.01	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Echinococcus multilocularis	serotonin receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	neuropeptides capa receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Echinococcus multilocularis	g-protein coupled receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	amine GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	myosin xvIII	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Echinococcus granulosus	serotonin receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	g protein coupled receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	amine GPCR	0.0097	0.7999	0.7999
Schistosoma mansoni	biogenic amine receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	7tm_1 domain containing protein	0.0097	0.7999	0.7999
Echinococcus granulosus	g-protein coupled receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Onchocerca volvulus		0.0097	0.7999	0.5
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0097	0.7999	0.7999
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0097	0.7999	0.7999
Schistosoma mansoni	growth hormone secretagogue receptor	0.0097	0.7999	0.7999
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0097	0.7999	0.7999
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.7999	0.7999
Onchocerca volvulus		0.0097	0.7999	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.7999	0.7999
Echinococcus granulosus	allatostatin A receptor	0.0097	0.7999	0.7999

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	= 25 uM	50% growth inhibition of G401 (human kidney carcinoma) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 25 uM	50% growth inhibition of G401 (human kidney carcinoma) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 40 uM	50% growth inhibition of A2780 (Human ovarian carcinoma) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 40 uM	50% growth inhibition of A2780 (Human ovarian carcinoma) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 41 uM	50% growth inhibition of H460 (human lung carcinoma) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 41 uM	50% growth inhibition of H460 (human lung carcinoma) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 48 uM	50% growth inhibition of L1210 (murine leukemia) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 48 uM	50% growth inhibition of L1210 (murine leukemia) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 49 uM	50% growth inhibition of HT-29 (human colorectal carcinoma) cell line compared with untreated control cells	ChEMBL.	15050639
GI50 (functional)	= 49 uM	50% growth inhibition of HT-29 (human colorectal carcinoma) cell line compared with untreated control cells	ChEMBL.	15050639
IC50 (binding)	= 3.2 uM	Inhibitory activity against protein phosphatase 2A from human red blood cells	ChEMBL.	15050639
IC50 (binding)	= 18 uM	Inhibitory activity against protein phosphatase-1 from rabbit skeletal muscle	ChEMBL.	15050639
IC50 (binding)	= 18 uM	Inhibitory activity against protein phosphatase-1 from rabbit skeletal muscle	ChEMBL.	15050639

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL368311

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 308523