Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Brugia malayi | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0048 | 0.2274 | 0.2274 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0.2274 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0089 | 0.7127 | 0.6282 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0089 | 0.7127 | 0.7127 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0085 | 0.6645 | 0.6645 |
Brugia malayi | Blistered cuticle protein 3 | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0113 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.2274 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0097 | 0.8069 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0048 | 0.2274 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.2274 | 0.5 |
Brugia malayi | Peroxidasin | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.2274 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.2274 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0085 | 0.6645 | 0.5657 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.2274 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.2274 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0048 | 0.2274 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2274 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.2274 | 0.5 | |
Onchocerca volvulus | 0.0048 | 0.2274 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0048 | 0.2274 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.25 uM | In vitro inhibitory activity of the compound against prostaglandin G/H synthase 2 from ovine | ChEMBL. | 15050635 |
IC50 (binding) | = 1.25 uM | In vitro inhibitory activity of the compound against prostaglandin G/H synthase 2 from ovine | ChEMBL. | 15050635 |
IC50 (binding) | = 31.6 uM | In vitro inhibitory activity of the compound against prostaglandin G/H synthase 1 from ovine | ChEMBL. | 15050635 |
IC50 (binding) | = 31.6 uM | In vitro inhibitory activity of the compound against prostaglandin G/H synthase 1 from ovine | ChEMBL. | 15050635 |
Selectivity (binding) | = 25.3 | Selectivity expressed as IC50 COX-1/IC50 COX-2 | ChEMBL. | 15050635 |
Selectivity (binding) | = 25.3 | Selectivity expressed as IC50 COX-1/IC50 COX-2 | ChEMBL. | 15050635 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.