Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0271 | 0.0954 | 0.0117 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.021 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0563 | 0.5477 | 0.5059 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0271 | 0.0954 | 0.0954 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0624 | 0.6432 | 0.6101 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0271 | 0.0954 | 0.0954 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0271 | 0.0954 | 0.0117 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0624 | 0.6432 | 0.6432 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0563 | 0.5477 | 0.5477 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0271 | 0.0954 | 0.0954 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0854 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0271 | 0.0954 | 0.0954 |
Brugia malayi | Glutamate receptor 1 precursor | 0.021 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0271 | 0.0954 | 0.0117 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0834 | 0.9694 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0291 | 0.126 | 0.126 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.021 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0265 | 0.0847 | 0.0874 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0271 | 0.0954 | 0.0117 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0271 | 0.0954 | 0.0117 |
Brugia malayi | Glutamate receptor 2 precursor | 0.021 | 0 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0265 | 0.0847 | 0.0847 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0271 | 0.0954 | 0.0954 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | Inhibitory activity against Methicillin-resistant S. epidermidis UC12084 | ChEMBL. | 10715160 |
MIC (functional) | = 1 ug ml-1 | Inhibitory activity against S. pneumoniae UC9912 | ChEMBL. | 10715160 |
MIC (functional) | = 4 ug ml-1 | Inhibitory activity against Methicillin-susceptible S. aureus UC9213 | ChEMBL. | 10715160 |
MIC (functional) | = 4 ug ml-1 | Inhibitory activity against Methicillin-resistant S. aureus UC6685 | ChEMBL. | 10715160 |
MIC (functional) | = 4 ug ml-1 | Inhibitory activity against E. faecalis UC9217 | ChEMBL. | 10715160 |
MIC (functional) | > 16 ug ml-1 | Inhibitory activity against H. influenzae UC30063 | ChEMBL. | 10715160 |
MIC (functional) | = 16 ug ml-1 | Inhibitory activity against M. catarrhalis UC30610 | ChEMBL. | 10715160 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.