Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycogen phosphorylase | 0.0495 | 0.562 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0495 | 0.562 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0495 | 0.562 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.0173 | 0.0308 |
Echinococcus granulosus | glycogen phosphorylase | 0.0495 | 0.562 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.0173 | 0.0308 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0113 | 0.0953 | 0.3879 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.0173 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.0173 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0495 | 0.562 | 0.5543 |
Brugia malayi | glutathione reductase | 0.005 | 0.0173 | 0.0308 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0214 | 0.2183 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0495 | 0.562 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0495 | 0.562 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0113 | 0.0953 | 0.3879 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0126 | 0.1108 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0113 | 0.0953 | 0.3879 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0201 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0201 | 0.0358 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0495 | 0.562 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0495 | 0.562 | 0.5543 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0495 | 0.562 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0126 | 0.1108 | 0.465 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0126 | 0.1108 | 0.465 |
Schistosoma mansoni | glycogen phosphorylase | 0.0495 | 0.562 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0113 | 0.0953 | 0.3879 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.0173 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0201 | 0.0358 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.0173 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0495 | 0.562 | 0.5543 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0201 | 0.0358 |
Giardia lamblia | Glycogen phosphorylase | 0.0495 | 0.562 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0113 | 0.0953 | 0.3879 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.0173 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.0173 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0495 | 0.562 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0495 | 0.562 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.0173 | 0.0308 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0113 | 0.0953 | 0.3879 |
Leishmania major | trypanothione reductase | 0.005 | 0.0173 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0495 | 0.562 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.0173 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0214 | 0.2183 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0126 | 0.1108 | 0.465 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0495 | 0.562 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0214 | 0.2183 | 0.3884 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 47 % | Inhibition by compound relative toCsA (100%), of cellular P-glycoprotein-mediated daunomycin effluxby its intracellular accumulation in K562/R7 human leukemic cells | ChEMBL. | 14761200 |
Inhibition (functional) | = 47 % | Inhibition by compound relative toCsA (100%), of cellular P-glycoprotein-mediated daunomycin effluxby its intracellular accumulation in K562/R7 human leukemic cells | ChEMBL. | 14761200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.