Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor NMDA | 0.0305 | 0.0719 | 0.0751 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.025 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0356 | 0.1393 | 0.1393 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0981 | 0.9577 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0324 | 0.097 | 0.027 |
Brugia malayi | Glutamate receptor 1 precursor | 0.025 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1013 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0324 | 0.097 | 0.097 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0324 | 0.097 | 0.097 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0305 | 0.0719 | 0.0719 |
Brugia malayi | Glutamate receptor 2 precursor | 0.025 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0324 | 0.097 | 0.027 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0324 | 0.097 | 0.027 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0657 | 0.5335 | 0.4973 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0324 | 0.097 | 0.097 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.025 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0324 | 0.097 | 0.027 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0324 | 0.097 | 0.097 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0657 | 0.5335 | 0.5335 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0731 | 0.6305 | 0.6305 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0324 | 0.097 | 0.097 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0324 | 0.097 | 0.027 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0731 | 0.6305 | 0.6018 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.126 uM | Inhibitory concentration of the compound against wild-type HIV-1 LAI Virus was determined | ChEMBL. | 15771435 |
IC50 (functional) | = 3.981 uM | Inhibitory concentration of the compound against 100I mutant was determined | ChEMBL. | 15771435 |
IC50 (functional) | = 3.981 uM | Inhibitory concentration of the compound against 103N mutant was determined | ChEMBL. | 15771435 |
IC50 (functional) | > 10 uM | Inhibitory concentration of the compound against 181C mutant was determined | ChEMBL. | 15771435 |
IC50 (functional) | > 10 uM | Inhibitory concentration of the compound against 188L mutant was determined | ChEMBL. | 15771435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.