Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0221 | 0.0226 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0088 | 0.6624 | 0.6774 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0088 | 0.6624 | 0.67 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0221 | 0.0226 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0036 | 0.0221 | 0.0226 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0081 | 0.5698 | 0.573 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0114 | 0.9779 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0036 | 0.0221 | 0.0226 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0081 | 0.5698 | 0.5826 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0036 | 0.0221 | 0.0226 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0114 | 0.9779 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.5 nM | Displacement of [3H]-nitrendipine binding to L-type calcium channel of Guinea pig cerebral cortex membranes | ChEMBL. | 1552511 |
IC50 (functional) | = 10.9 nM | Molar concentration of the compound required to block [Ca2+] induced contraction of K+ depolarized rat aorta by 50% | ChEMBL. | 1552511 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.