Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0461 | 0.0461 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.2295 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0992 | 0.4278 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0461 | 0.0461 |
Brugia malayi | amidase | 0.0123 | 0.0461 | 0.0461 |
Schistosoma mansoni | glycogen phosphorylase | 0.0992 | 0.4278 | 0.4278 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.0461 | 0.0461 |
Schistosoma mansoni | amidase | 0.0123 | 0.0461 | 0.0461 |
Echinococcus multilocularis | glycogen phosphorylase | 0.2295 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.2295 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0992 | 0.4278 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.2295 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.2295 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.2295 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0992 | 0.4278 | 0.4278 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.2295 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.2295 | 1 | 1 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0992 | 0.4278 | 0.4278 |
Echinococcus granulosus | glycogen phosphorylase | 0.2295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0461 | 0.0461 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.0461 | 0.0461 |
Echinococcus granulosus | glycogen phosphorylase | 0.2295 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.2295 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.2295 | 1 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.0461 | 0.0461 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.2295 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.2295 | 1 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.2295 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.2295 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0992 | 0.4278 | 0.4278 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.018 uM | Inhibitory constant determined against recombinant Fatty-acid amide hydrolase from rat expressed in Escherichia coli | ChEMBL. | 15771430 |
Ki (binding) | = 0.018 uM | Inhibitory constant determined against recombinant Fatty-acid amide hydrolase from rat expressed in Escherichia coli | ChEMBL. | 15771430 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.