Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3302 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0164 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0055 | 0.2536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0671 | 0.0557 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0671 | 0.0671 |
Brugia malayi | RNA binding protein | 0.0066 | 0.3302 | 0.3302 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3302 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.3302 | 0.322 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0671 | 0.2279 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0121 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0671 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.3302 | 0.322 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3302 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0055 | 0.2536 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0121 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0671 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0671 | 0.2279 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0055 | 0.2536 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.3302 | 0.322 |
Echinococcus multilocularis | muscleblind protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.3302 | 0.322 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0055 | 0.2536 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0055 | 0.2536 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0055 | 0.2536 | 0.7592 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0671 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0164 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0121 | 0.0121 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0121 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3302 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.3302 | 0.3302 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0671 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0121 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0055 | 0.2536 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0121 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0055 | 0.2536 | 0.2445 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.3302 | 0.3302 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0671 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0055 | 0.2536 | 0.2445 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.3302 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0055 | 0.2536 | 0.7592 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0121 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.3302 | 0.322 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0671 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 47 % | Percent inhibition of [3H]-PSB-11 binding to adenosine A3 receptor at 10 uM | ChEMBL. | 15771453 |
Ki (binding) | = 8.23 nM | Inhibition of [3H]-CCPA binding to adenosine A1 receptor | ChEMBL. | 15771453 |
Ki (binding) | = 3100 nM | Inhibition of [3H]-PSB-298 binding to adenosine A2b receptor | ChEMBL. | 15771453 |
Ki (binding) | = 3800 nM | Inhibition of [3H]-MSX-2 binding to adenosine A2a receptor | ChEMBL. | 15771453 |
Ki (binding) | ~ 10000 nM | Inhibition of [3H]-PSB-11 binding to adenosine A3 receptor | ChEMBL. | 15771453 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.