Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0264 | 0.2927 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0264 | 0.2927 | 0.1129 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0264 | 0.2927 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0264 | 0.2927 | 0.1129 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0264 | 0.2927 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2927 | 0.1129 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0407 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0264 | 0.2927 | 0.5 |
Onchocerca volvulus | 0.0344 | 0.6891 | 0.5604 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0407 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0264 | 0.2927 | 1 |
Onchocerca volvulus | 0.0407 | 1 | 1 | |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0264 | 0.2927 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0264 | 0.2927 | 0.1129 |
Leishmania major | hypothetical protein, conserved | 0.0264 | 0.2927 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.7 nM | Binding affinity for transfected human Corticotropin releasing factor receptor expressed in HEK 293E cells using [125I]-TYR-oCRH as the displaced radioligand | ChEMBL. | 10230622 |
Ki (binding) | = 5.7 nM | Binding affinity for transfected human Corticotropin releasing factor receptor expressed in HEK 293E cells using [125I]-TYR-oCRH as the displaced radioligand | ChEMBL. | 10230622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.