Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hedgehog | 0.0195 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.0008 | 0 | 0.5 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0008 | 0 | 0.5 |
Brugia malayi | Hint module family protein | 0.0053 | 0.242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.242 | 1 |
Brugia malayi | Hint module family protein | 0.0053 | 0.242 | 1 |
Trypanosoma cruzi | UDP-glucoronosyl and UDP-glucosyl transferase, putative | 0.0028 | 0.1062 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.242 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.7174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1062 | 0.4389 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 47 uM | Binding affinity for human liver monoamine oxidase A | ChEMBL. | 15658863 |
Ki (binding) | = 47 uM | Binding affinity for human liver monoamine oxidase A | ChEMBL. | 15658863 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration of the compound against penicillin susceptible Streptococcus pneumoniae AP671401 | ChEMBL. | 15658863 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration of the compound against Haemophilius influenzae ATCC51907 | ChEMBL. | 15658863 |
MIC (functional) | = 32 ug ml-1 | Minimum inhibitory concentration of the compound against methicillin susceptible Staphylococcus aureus AP601055 | ChEMBL. | 15658863 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.