Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 3600 nM | Effective concentration against rat transient receptor potential vanilloid 1 receptor (n=6) | ChEMBL. | 15771431 |
EC50 (binding) | = 3600 nM | Effective concentration against rat transient receptor potential vanilloid 1 receptor (n=6) | ChEMBL. | 15771431 |
EC50 (binding) | = 7240 nM | Effective concentration against human transient receptor potential vanilloid 1 receptor (n=6) | ChEMBL. | 15771431 |
EC50 (binding) | = 7240 nM | Effective concentration against human transient receptor potential vanilloid 1 receptor (n=6) | ChEMBL. | 15771431 |
Efficacy (binding) | > 40 % | Percentage efficacy against rat transient receptor potential vanilloid 1 receptor (n=3) | ChEMBL. | 15771431 |
Efficacy (binding) | > 40 % | Percentage efficacy against rat transient receptor potential vanilloid 1 receptor (n=3) | ChEMBL. | 15771431 |
Efficacy (binding) | = 100 % | Percentage efficacy against human transient receptor potential vanilloid 1 receptor (n=3) | ChEMBL. | 15771431 |
Efficacy (binding) | = 100 % | Percentage efficacy against human transient receptor potential vanilloid 1 receptor (n=3) | ChEMBL. | 15771431 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.