Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nmda type glutamate receptor | 0.1552 | 0.304 | 0.304 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.2519 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1552 | 0.304 | 0.1439 |
Schistosoma mansoni | glutamate receptor NMDA | 0.2161 | 0.7419 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.139 | 0.187 | 0.187 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Inhibition of colon carcinoma cell line (SW 620) growth | ChEMBL. | 15658861 |
IC50 (functional) | >= 100 uM | Inhibition of laryngeal carcinoma cell line (Hep-2) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 100 uM | Inhibition of pancreatic carcinoma cell line (MiaPaCa-2) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 100 uM | Inhibition of breast carcinoma cell line (MCF-7) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 100 uM | Inhibition of cervical carcinoma cell line (HeLa) growth | ChEMBL. | 15658861 |
IC50 (functional) | >= 100 uM | Inhibition of normal human fibroblast cell line (WI 38) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 100 uM | Inhibition of colon carcinoma cell line (SW 620) growth | ChEMBL. | 15658861 |
IC50 (functional) | >= 100 uM | Inhibition of laryngeal carcinoma cell line (Hep-2) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 100 uM | Inhibition of pancreatic carcinoma cell line (MiaPaCa-2) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 100 uM | Inhibition of breast carcinoma cell line (MCF-7) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 100 uM | Inhibition of cervical carcinoma cell line (HeLa) growth | ChEMBL. | 15658861 |
IC50 (functional) | >= 100 uM | Inhibition of normal human fibroblast cell line (WI 38) growth | ChEMBL. | 15658861 |
IC50 (functional) | = 192 uM | Inhibition of human T-lymphocyte cell line (Molt4/C8) growth | ChEMBL. | 15658861 |
IC50 (functional) | = 192 uM | Inhibition of human T-lymphocyte cell line (Molt4/C8) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 200 uM | Inhibition of murine leukemia cells (L1210) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 200 uM | Inhibition of human T-lymphocyte cell line (CEM) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 200 uM | Inhibition of murine leukemia cells (L1210) growth | ChEMBL. | 15658861 |
IC50 (functional) | > 200 uM | Inhibition of human T-lymphocyte cell line (CEM) growth | ChEMBL. | 15658861 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.