Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 3 nM | In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 3 nM | In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 3 nM | In vitro inhibition of PMA-activated human TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 4 nM | In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 4 nM | In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 4 nM | In vitro inhibition of acid activated rat TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 4 nM | In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 5 nM | In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 5 nM | In vitro inhibition of anandamide activated human TRPV1 receptor in [Ca2+] influx assay | ChEMBL. | 15771431 |
IC50 (binding) | = 57 nM | Inhibition of human transient receptor potential vanilloid 1 receptor (n=13) | ChEMBL. | 15771431 |
IC50 (binding) | = 57 nM | Inhibition of human transient receptor potential vanilloid 1 receptor (n=13) | ChEMBL. | 15771431 |
IC50 (binding) | = 90 nM | Inhibition of rat transient receptor potential vanilloid 1 receptor (n=4) | ChEMBL. | 15771431 |
IC50 (binding) | = 90 nM | Inhibition of rat transient receptor potential vanilloid 1 receptor (n=4) | ChEMBL. | 15771431 |
Ki (binding) | = 38 nM | Displacement of [3H]-resiniferatoxin from human Transient receptor potential vanilloid 1 receptor; (n=2) | ChEMBL. | 15771431 |
Ki (binding) | = 38 nM | Displacement of [3H]-resiniferatoxin from human Transient receptor potential vanilloid 1 receptor; (n=2) | ChEMBL. | 15771431 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.