Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0019 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0019 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0019 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0019 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0019 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0019 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0019 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0019 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0019 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0019 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0019 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of human cAMP-dependent protein kinase (PKA) | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Protein kinase B alpha at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Glycogen synthase kinase-3 beta at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human lymphocyte protein tyrosine kinase Lck at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human cAMP-dependent protein kinase (PKA) | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Protein kinase B alpha at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human Glycogen synthase kinase-3 beta at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 0 % | Inhibition of human lymphocyte protein tyrosine kinase Lck at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 1 % | Inhibition of human Mitogen-activated protein kinase 2 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 1 % | Inhibition of human Mitogen-activated protein kinase 2 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 4 % | Inhibition of human Mitogen activated protein kinase kinase 1 (MEK1) at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 4 % | Inhibition of human Mitogen activated protein kinase kinase 1 (MEK1) at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 6 % | Inhibition of human c-Jun N-terminal kinase-1 alpha1 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 6 % | Inhibition of human c-Jun N-terminal kinase-1 alpha1 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 7 % | Inhibition of human Rho-dependent protein kinase-II at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 7 % | Inhibition of human Rho-dependent protein kinase-II at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 8 % | Inhibition of rat Calcium/calmodulin-dependent protein kinase type II at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 8 % | Inhibition of rat Calcium/calmodulin-dependent protein kinase type II at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 9 % | Inhibition of human c-Jun N-terminal kinase-2 alpha2 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 9 % | Inhibition of human c-Jun N-terminal kinase-2 alpha2 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 13 % | Inhibition of human Protein kinase C alpha | ChEMBL. | 15689155 |
Inhibition (binding) | = 13 % | Inhibition of human Protein kinase C alpha | ChEMBL. | 15689155 |
Inhibition (binding) | = 16 % | Inhibition of human Mitogen-activated protein kinase 1 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 16 % | Inhibition of human Mitogen-activated protein kinase 1 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 17 % | Inhibition of human stress-activated protein kinase-2 alpha (p38 MAP-kinase) at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 17 % | Inhibition of human stress-activated protein kinase-2 alpha (p38 MAP-kinase) at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 20 % | Inhibition of human RAF proto-oncogene serine/threonine-protein kinase at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 20 % | Inhibition of human RAF proto-oncogene serine/threonine-protein kinase at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 21 % | Inhibition of rat c-Jun N-terminal kinase-3 at 30 uM | ChEMBL. | 15689155 |
Inhibition (binding) | = 21 % | Inhibition of rat c-Jun N-terminal kinase-3 at 30 uM | ChEMBL. | 15689155 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.