Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | prolyl endopeptidase | 0.0167 | 0.6816 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0081 | 0.0402 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.9328 | 0.7889 |
Trypanosoma brucei | prolyl endopeptidase | 0.0167 | 0.6816 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0081 | 0.0402 | 0.059 |
Brugia malayi | Trypsin family protein | 0.02 | 0.9328 | 0.93 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0081 | 0.0402 | 0.059 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0167 | 0.6816 | 0.6683 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 1 | 1 |
Onchocerca volvulus | 0.0183 | 0.7996 | 0.3706 | |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0081 | 0.0402 | 0.059 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0167 | 0.6816 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0136 | 0.4483 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0081 | 0.0402 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.9328 | 0.7889 |
Toxoplasma gondii | prolyl endopeptidase | 0.0167 | 0.6816 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.02 | 0.9328 | 0.93 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0167 | 0.6816 | 0.6683 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.02 | 0.9328 | 0.93 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0167 | 0.6816 | 0.6683 |
Onchocerca volvulus | 0.02 | 0.9328 | 0.7889 | |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0167 | 0.6816 | 0.6683 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0167 | 0.6816 | 0.6683 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0076 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.4 % | Percentage of content of the compound in MCF-7 human breast cancer cell nuclei was reported | ChEMBL. | 15658875 |
Activity (functional) | = 2 % | Percentage of content of the compound in MDA-MB 231 human breast cancer cell nuclei was reported | ChEMBL. | 15658875 |
Activity (functional) | = 0.15 pmol/ug | Content of the compound in MCF-7 human breast cancer cell nuclei was reported | ChEMBL. | 15658875 |
Activity (functional) | = 0.15 pmol/ug | Content of the compound in MDA-MB 231 human breast cancer cell nuclei was reported | ChEMBL. | 15658875 |
Activity (binding) | = 33.94 pmol/ug | DNA-binding efficacy | ChEMBL. | 15658875 |
IC50 (functional) | = 7 uM | Antiproliferative activity of the compound was determined in MCF-7 human breast cancer cells | ChEMBL. | 15658875 |
IC50 (functional) | > 50 uM | Antiproliferative activity of the compound was determined in MDA-MB 231 human breast cancer cells | ChEMBL. | 15658875 |
Log Kw | = 3.55 | Lipophilicity of the compound was reported | ChEMBL. | 15658875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.