Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.3037 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.3037 | 1 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0167 | 0.2243 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0534 | 1 | 1 |
Trypanosoma brucei | squalene synthase, putative | 0.0534 | 1 | 0.5 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0167 | 0.2243 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.2243 | 0.5745 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.3905 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.3905 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2243 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0534 | 1 | 1 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0167 | 0.2243 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 18000 nM | Inhibtion of [125I]-Tyr-o-CRF binding to Corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cells | ChEMBL. | 15603967 |
Ki (binding) | = 18000 nM | Inhibtion of [125I]-Tyr-o-CRF binding to Corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cells | ChEMBL. | 15603967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.