Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | Starlite/ChEMBL | References |
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | Starlite/ChEMBL | References |
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, beta 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131775 | All targets in OG5_131775 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 467 aa | 449 aa | 27.6 % |
Brugia malayi | excitatory GABA receptor EXP-1A | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 473 aa | 441 aa | 29.9 % |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 451 aa | 393 aa | 25.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glycosyl transferase family 35 | 0.1685 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.1685 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 0.1332 | 0.1332 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.1685 | 1 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0729 | 0.347 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1685 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.1685 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.1685 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.1685 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.0142 | 0.0142 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1685 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1685 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1685 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.1685 | 1 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0729 | 0.347 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1685 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.1685 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1685 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.1685 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.1685 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (binding) | = 33 % | Efficacy of the compound was measured as modulation of the current in response to GABA at hGABA alpha3-beta3-gamma2 receptor expressed in Xenopus oocytes | ChEMBL. | 15743180 |
Efficacy (binding) | = 33 % | Efficacy of the compound was measured as modulation of the current in response to GABA at hGABA alpha3-beta3-gamma2 receptor expressed in Xenopus oocytes | ChEMBL. | 15743180 |
Efficacy (binding) | = 41 % | Efficacy of the compound was measured as modulation of the current in response to GABA at hGABA alpha1-beta3-gamma2 receptor expressed in Xenopus oocytes | ChEMBL. | 15743180 |
Efficacy (binding) | = 41 % | Efficacy of the compound was measured as modulation of the current in response to GABA at hGABA alpha1-beta3-gamma2 receptor expressed in Xenopus oocytes | ChEMBL. | 15743180 |
Ki (binding) | = 2 nM | Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 subtype expressed in L (tk-) cells | ChEMBL. | 15743180 |
Ki (binding) | = 2 nM | Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 subtype expressed in L (tk-) cells | ChEMBL. | 15743180 |
Ki (binding) | = 18 nM | Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 subtype expressed in L (tk-) cells | ChEMBL. | 15743180 |
Ki (binding) | = 18 nM | Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 subtype expressed in L (tk-) cells | ChEMBL. | 15743180 |
Ki (binding) | = 19 nM | Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric acid A receptor alpha2-beta3-gamma2 subtype expressed in L (tk-) cells | ChEMBL. | 15743180 |
Ki (binding) | = 19 nM | Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric acid A receptor alpha2-beta3-gamma2 subtype expressed in L (tk-) cells | ChEMBL. | 15743180 |
Ki (binding) | = 93 nM | Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 subtype expressed in L (tk-) cells | ChEMBL. | 15743180 |
Ki (binding) | = 93 nM | Inhibition of [3H]-Ro-15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 subtype expressed in L (tk-) cells | ChEMBL. | 15743180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.