Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | lanosterol synthase | 0.0317 | 0.0918 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1269 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.3965 | 0.0935 |
Schistosoma mansoni | calcium-activated potassium channel | 0.1269 | 1 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0317 | 0.0918 | 0.5 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0317 | 0.0918 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1269 | 1 | 1 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.022 | 0 | 0.5 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.1269 | 1 | 0.5 |
Leishmania major | lanosterol synthase, putative | 0.0287 | 0.0637 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 30000 nM | In vitro activity of the compound to inhibit MCP-1-induced leukocyte migration of THP-1 cells | ChEMBL. | 15689171 |
ED50 (functional) | = 30000 nM | In vitro activity of the compound to inhibit MCP-1-induced leukocyte migration of THP-1 cells | ChEMBL. | 15689171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.