Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutamate receptor kainate | 0.0612 | 0.4374 | 0.1133 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0537 | 0.2896 | 0.2171 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0867 | 0.9357 | 0.9292 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0436 | 0.0926 | 0.0926 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0703 | 0.6144 | 0.6144 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.09 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0632 | 0.4768 | 0.4235 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0776 | 0.7587 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0703 | 0.6144 | 0.5751 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0537 | 0.2896 | 0.2896 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0851 | 0.904 | 0.8488 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0703 | 0.6144 | 0.6144 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0867 | 0.9357 | 0.9357 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0703 | 0.6144 | 0.6144 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0632 | 0.4768 | 0.4768 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0703 | 0.6144 | 0.5751 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0776 | 0.7587 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0776 | 0.7587 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0703 | 0.6144 | 0.5751 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0867 | 0.9357 | 0.9357 |
Echinococcus granulosus | glutamate receptor 2 | 0.0867 | 0.9357 | 0.9292 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0776 | 0.7587 | 0.7587 |
Schistosoma mansoni | glutamate receptor NMDA | 0.09 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0612 | 0.4374 | 0.1133 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.3 uM | Inhibitory concentration of thecompound was determined againstmelanocyte Mel-A cells | ChEMBL. | 15634028 |
IC50 (functional) | = 2.3 uM | Inhibitory concentration of thecompound was determined againstmelanocyte Mel-A cells | ChEMBL. | 15634028 |
IC50 (functional) | = 2.5 uM | Inhibitory concentration of thecompound was determined againstmelanoma B16 cells | ChEMBL. | 15634028 |
IC50 (functional) | = 2.5 uM | Inhibitory concentration of thecompound was determined againstmelanoma B16 cells | ChEMBL. | 15634028 |
IC50 (functional) | = 7.6 uM | Inhibitory concentration of thecompound was determined against L1210 cells | ChEMBL. | 15634028 |
IC50 (functional) | = 7.6 uM | Inhibitory concentration of thecompound was determined against L1210 cells | ChEMBL. | 15634028 |
IC50 (binding) | > 1000 uM | Inhibitory concentration against 20S proteasome chymotrypsin-like activity | ChEMBL. | 15634028 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15634028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.