Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0057 | 0.0057 |
Plasmodium falciparum | cyclin | 0.0223 | 0.031 | 0.1634 |
Brugia malayi | cell division control protein 2 homolog | 0.0318 | 0.1897 | 0.2322 |
Brugia malayi | Protein kinase domain containing protein | 0.0318 | 0.1897 | 0.2322 |
Trichomonas vaginalis | cyclins, putative | 0.0262 | 0.0964 | 0.2525 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0318 | 0.1897 | 0.1897 |
Echinococcus granulosus | cyclins | 0.0223 | 0.031 | 0.031 |
Trichomonas vaginalis | cyclin D, putative | 0.0223 | 0.031 | 0.0812 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0318 | 0.1897 | 0.4968 |
Trichomonas vaginalis | cyclins, putative | 0.0432 | 0.3818 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0318 | 0.1897 | 0.4968 |
Giardia lamblia | Kinase, CMGC CDK | 0.0318 | 0.1897 | 0.4968 |
Echinococcus multilocularis | cyclins | 0.0223 | 0.031 | 0.031 |
Trichomonas vaginalis | cyclin B, putative | 0.0223 | 0.031 | 0.0812 |
Echinococcus multilocularis | cyclins | 0.0223 | 0.031 | 0.031 |
Trypanosoma cruzi | cyclin, putative | 0.0432 | 0.3818 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0318 | 0.1897 | 0.1897 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0318 | 0.1897 | 0.4968 |
Leishmania major | cyclin | 0.0432 | 0.3818 | 1 |
Echinococcus multilocularis | cyclins | 0.0223 | 0.031 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.3818 | 0.3818 |
Echinococcus granulosus | cyclins | 0.0223 | 0.031 | 0.031 |
Echinococcus multilocularis | cyclin B | 0.0432 | 0.3818 | 0.3818 |
Schistosoma mansoni | cyclins | 0.0223 | 0.031 | 0.031 |
Giardia lamblia | Cyclin A | 0.0223 | 0.031 | 0.0812 |
Trichomonas vaginalis | cyclin B, putative | 0.0432 | 0.3818 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0432 | 0.3818 | 0.4674 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.2988 | 0.2988 |
Trichomonas vaginalis | cyclins, putative | 0.0223 | 0.031 | 0.0812 |
Trichomonas vaginalis | cyclins, putative | 0.0432 | 0.3818 | 1 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0318 | 0.1897 | 0.1897 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.2988 | 0.2988 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0318 | 0.1897 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0432 | 0.3818 | 0.4674 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0318 | 0.1897 | 0.1897 |
Trichomonas vaginalis | cyclin B, putative | 0.0432 | 0.3818 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0318 | 0.1897 | 0.1897 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0318 | 0.1897 | 0.4968 |
Plasmodium falciparum | protein kinase 5 | 0.0318 | 0.1897 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0318 | 0.1897 | 0.1897 |
Echinococcus granulosus | cyclin B3 1 | 0.0223 | 0.031 | 0.031 |
Echinococcus multilocularis | cyclins | 0.0223 | 0.031 | 0.031 |
Entamoeba histolytica | cyclin family protein | 0.0223 | 0.031 | 0.0812 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0318 | 0.1897 | 0.4968 |
Trypanosoma cruzi | cyclin, putative | 0.0432 | 0.3818 | 1 |
Echinococcus granulosus | cyclins | 0.0223 | 0.031 | 0.031 |
Schistosoma mansoni | cyclin B | 0.0432 | 0.3818 | 0.3818 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0318 | 0.1897 | 0.4968 |
Trichomonas vaginalis | cyclin A, putative | 0.0432 | 0.3818 | 1 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0318 | 0.1897 | 0.4968 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0318 | 0.1897 | 0.1897 |
Plasmodium vivax | protein kinase Crk2 | 0.0318 | 0.1897 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0432 | 0.3818 | 1 |
Echinococcus granulosus | cyclin B | 0.0432 | 0.3818 | 0.3818 |
Trichomonas vaginalis | cyclin D, putative | 0.0223 | 0.031 | 0.0812 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0799 | 1 | 1 |
Echinococcus granulosus | cyclin b3 | 0.0223 | 0.031 | 0.031 |
Schistosoma mansoni | cyclin B3 | 0.069 | 0.817 | 0.817 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.069 | 0.817 | 0.817 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.069 | 0.817 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0318 | 0.1897 | 0.4968 |
Echinococcus granulosus | cyclins | 0.0223 | 0.031 | 0.031 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0432 | 0.3818 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0318 | 0.1897 | 0.1897 |
Giardia lamblia | Kinase, CMGC CDK | 0.0318 | 0.1897 | 0.4968 |
Entamoeba histolytica | cyclin, putative | 0.0223 | 0.031 | 0.0812 |
Trichomonas vaginalis | cyclins, putative | 0.0432 | 0.3818 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.3818 | 0.3818 |
Trichomonas vaginalis | cyclin B, putative | 0.0432 | 0.3818 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0432 | 0.3818 | 1 |
Onchocerca volvulus | 0.0432 | 0.3818 | 1 | |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0318 | 0.1897 | 0.4968 |
Echinococcus multilocularis | cyclins | 0.0223 | 0.031 | 0.031 |
Entamoeba histolytica | cyclin family protein | 0.0223 | 0.031 | 0.0812 |
Loa Loa (eye worm) | hypothetical protein | 0.0799 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0318 | 0.1897 | 0.1897 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0799 | 1 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.069 | 0.817 | 0.817 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0432 | 0.3818 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0318 | 0.1897 | 0.1897 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0432 | 0.3818 | 1 |
Echinococcus multilocularis | cyclin b3 | 0.0223 | 0.031 | 0.031 |
Giardia lamblia | Hypothetical protein | 0.0223 | 0.031 | 0.0812 |
Echinococcus granulosus | cyclins | 0.0223 | 0.031 | 0.031 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0318 | 0.1897 | 0.1897 |
Trypanosoma cruzi | cyclin 6, putative | 0.0432 | 0.3818 | 1 |
Echinococcus multilocularis | cyclins | 0.0223 | 0.031 | 0.031 |
Brugia malayi | hypothetical protein | 0.0382 | 0.2988 | 0.3657 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.069 | 0.817 | 0.817 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0318 | 0.1897 | 0.1897 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0318 | 0.1897 | 0.4968 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.1808 | 0.1808 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0223 | 0.031 | 0.0812 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0318 | 0.1897 | 0.4968 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0318 | 0.1897 | 0.4968 |
Trichomonas vaginalis | cyclins, putative | 0.0432 | 0.3818 | 1 |
Echinococcus multilocularis | cyclins | 0.0223 | 0.031 | 0.031 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0318 | 0.1897 | 0.1897 |
Trichomonas vaginalis | cyclin B3, putative | 0.0223 | 0.031 | 0.0812 |
Echinococcus multilocularis | cyclin B3 1 | 0.0223 | 0.031 | 0.031 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0318 | 0.1897 | 0.4968 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0432 | 0.3818 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 119 nM | In vitro binding affinity of the compound against C-C chemokine receptor type 3 expressing in rat Y3 cell line | ChEMBL. | 15713390 |
Ki (binding) | = 119 nM | In vitro binding affinity of the compound against C-C chemokine receptor type 3 expressing in rat Y3 cell line | ChEMBL. | 15713390 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.