Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0119 | 0.5949 | 0.8166 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.7011 | 0.3903 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.7011 | 0.3903 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.7011 | 1 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.7011 | 0.3903 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0064 | 0.0733 | 0.0831 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.7011 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.7011 | 0.9829 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.7011 | 0.7942 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.7011 | 0.3903 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0162 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.011 | 0.5098 | 0.5775 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.7011 | 0.3903 |
Loa Loa (eye worm) | glutamate receptor | 0.0132 | 0.7121 | 0.0365 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 0.7011 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.015 | 0.8828 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.7011 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.7011 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0132 | 0.7121 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.7011 | 0.7942 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.7011 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.7011 | 0.3903 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.7011 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line); ND=Not determined | ChEMBL. | 15603973 |
IC50 (binding) | = 3 uM | Inhibitory concentration against glycogen phosphorylase | ChEMBL. | 15603973 |
IC50 (binding) | = 3 uM | Inhibitory concentration against glycogen phosphorylase | ChEMBL. | 15603973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.