Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.6275 | 0.6275 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.6275 | 0.6275 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0056 | 0.1284 | 0.1864 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.6275 | 0.6222 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.6275 | 0.6222 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0056 | 0.1284 | 0.1864 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.6275 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.6275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1165 | 0.1857 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.6275 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.014 | 0.014 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.6275 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.014 | 0.0224 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1165 | 0.1857 |
Echinococcus multilocularis | geminin | 0.0186 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.1284 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.6275 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0056 | 0.1284 | 0.1864 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.6275 | 0.6222 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.014 | 0.014 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1165 | 0.1857 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.1284 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.6275 | 0.6222 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1165 | 0.1857 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.6275 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.6275 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.6275 | 0.6222 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.1284 | 0.1284 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.6275 | 0.6222 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.6275 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 0.6275 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 30 % | Percentage of glucose lowering after 3h at minimum effective dose in mouse | ChEMBL. | 15603973 |
Activity (functional) | = 30 % | Percentage of glucose lowering after 3h at minimum effective dose in mouse | ChEMBL. | 15603973 |
IC50 (binding) | = 0.15 uM | Inhibitory concentration against glycogen phosphorylase | ChEMBL. | 15603973 |
IC50 (binding) | = 0.15 uM | Inhibitory concentration against glycogen phosphorylase | ChEMBL. | 15603973 |
IC50 (functional) | = 1.4 uM | Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line) | ChEMBL. | 15603973 |
IC50 (functional) | = 1.4 uM | Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line) | ChEMBL. | 15603973 |
MED (functional) | = 10 mg kg-1 | In-vivo minimum effectivedose (MED) for reduction of plasma glucose in mouse after 3 hours | ChEMBL. | 15603973 |
MED (functional) | = 10 mg kg-1 | In-vivo minimum effectivedose (MED) for reduction of plasma glucose in mouse after 3 hours | ChEMBL. | 15603973 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15603973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.