Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.0366 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0481 | 0.0294 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0481 | 0.0294 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0481 | 0.0294 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.1563 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0481 | 0.0294 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0448 | 0 | 0.5 |
Onchocerca volvulus | 0.0481 | 0.0294 | 0.5 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0481 | 0.0294 | 0.5 |
Onchocerca volvulus | 0.0481 | 0.0294 | 0.5 | |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0489 | 0.0366 | 0.5 |
Onchocerca volvulus | 0.0481 | 0.0294 | 0.5 | |
Brugia malayi | ShTK domain containing protein | 0.0481 | 0.0294 | 0.5 |
Onchocerca volvulus | 0.0481 | 0.0294 | 0.5 | |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0489 | 0.0366 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1680 nM | Binding affinity for adenosine A2b receptor by using as [3H]-ZM-241,385 (14 nM) radioligand in membranes from HEK-A2B cells | ChEMBL. | 15664822 |
Ki (binding) | = 1680 nM | Binding affinity for adenosine A2b receptor by using as [3H]-ZM-241,385 (14 nM) radioligand in membranes from HEK-A2B cells | ChEMBL. | 15664822 |
Ki (binding) | > 5000 nM | Binding affinity for adenosine A2a receptor by using as [3H]-ZM-241,385 (2 nM) radioligand in membranes from HEK-A2A cells | ChEMBL. | 15664822 |
Ki (binding) | > 5000 nM | Binding affinity for adenosine A2a receptor by using as [3H]-ZM-241,385 (2 nM) radioligand in membranes from HEK-A2A cells | ChEMBL. | 15664822 |
Ki (binding) | > 6000 nM | Binding affinity for adenosine A1 receptor by using as [3H]-CPX (0.5 nM) radioligand in membranes from Chinese hamster ovary cells | ChEMBL. | 15664822 |
Ki (binding) | > 6000 nM | Binding affinity for adenosine A1 receptor by using as [3H]-CPX (0.5 nM) radioligand in membranes from Chinese hamster ovary cells | ChEMBL. | 15664822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.