Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.6275 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.6275 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.6275 | 0.6222 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.1284 | 0.1284 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.6275 | 0.6222 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.6275 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 0.6275 | 0.5 |
Echinococcus multilocularis | geminin | 0.0186 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0056 | 0.1284 | 0.1864 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.6275 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.1284 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.6275 | 0.6222 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.014 | 0.014 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.1284 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1165 | 0.1857 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.6275 | 0.6222 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1165 | 0.1857 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.6275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1165 | 0.1857 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.014 | 0.014 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.6275 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0.014 | 0.0224 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.6275 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1165 | 0.1857 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.6275 | 0.6275 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0056 | 0.1284 | 0.1864 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.6275 | 0.6275 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.6275 | 0.6222 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.6275 | 0.6222 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0056 | 0.1284 | 0.1864 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.6275 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.016 uM | Inhibitory concentration against glycogen phosphorylase | ChEMBL. | 15603973 |
IC50 (binding) | = 0.016 uM | Inhibitory concentration against glycogen phosphorylase | ChEMBL. | 15603973 |
IC50 (functional) | = 1.3 uM | Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line) | ChEMBL. | 15603973 |
IC50 (functional) | = 1.3 uM | Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line) | ChEMBL. | 15603973 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15603973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.