Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | adenosine kinase | 0.124 | 1 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.124 | 1 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.124 | 1 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.124 | 1 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.124 | 1 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.124 | 1 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.124 | 1 | 0.5 |
Onchocerca volvulus | 0.1099 | 0 | 0.5 | |
Echinococcus multilocularis | adenosine kinase | 0.124 | 1 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.124 | 1 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.124 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.124 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.03 ug ml-1 | Minimum inhibitory concentrationof the compound against erythromycin-susceptible Streptococcus pneumoniae was determined | ChEMBL. | 15686880 |
MIC (functional) | = 0.06 ug ml-1 | Minimum inhibitory concentrationof the compound against 3 erythromycin-susceptible Streptococcus pneumoniae OC4051 with an erm(B)-ribosomal methylase-mediated resistance was determined | ChEMBL. | 15686880 |
MIC (functional) | = 0.12 ug ml-1 | Minimum inhibitory concentrationof the compound against erythromycin-susceptible Staphylococcus aureus Smith OC4172 was determined | ChEMBL. | 15686880 |
MIC (functional) | = 0.12 ug ml-1 | Minimum inhibitory concentrationof the compound against 3 erythromycin-susceptible Streptococcus pneumoniae OC4421 with an mef(A) efflux-mediated resistance was determined | ChEMBL. | 15686880 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentrationof the compound against erythromycin-susceptible Staphylococcusaureus Smith OC4172 in 50% mouse serum was determined | ChEMBL. | 15686880 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentrationof the compound against Haemophilus influenzae OC4882 was determined | ChEMBL. | 15686880 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentrationof the compound against erythromycin-susceptible Staphylococcusaureus Smith OC4172 in 50% mouse serum was determined | ChEMBL. | 15686880 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentrationof the compound againstEnterococcus faecalis ATCC51299 with an erm(B)-encoded ribosomalmethylase was determined | ChEMBL. | 15686880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.