Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0131 | 0.85 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0146 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0131 | 0.85 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0139 | 0.9342 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0048 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0106 | 0.5902 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0146 | 1 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0146 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.5096 | 0.4103 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0146 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0131 | 0.85 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.5096 | 0.4103 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0146 | 1 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0146 | 1 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0146 | 1 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0106 | 0.5902 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0146 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0079 | 0.3184 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0106 | 0.5902 | 0.5 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0146 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0048 | 0 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0146 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0146 | 1 | 0.5 |
Leishmania major | DNA topoisomerase ii | 0.0131 | 0.85 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0048 | 0 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0131 | 0.85 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.77 | Antagonist activity against human recombinant cannabinoid-1 receptor | ChEMBL. | 19406638 |
IC50 (binding) | = 170 nM | Inhibitory concentration against human recombinant cannabinoid receptor type 1 expressed in Chinese Hamster Ovary (CHO) cells | ChEMBL. | 15713403 |
IC50 (binding) | = 170 nM | Inhibitory concentration against human recombinant cannabinoid receptor type 1 expressed in Chinese Hamster Ovary (CHO) cells | ChEMBL. | 15713403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.