Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0315 | 0.8884 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0315 | 0.8884 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0183 | 0.3835 | 0.4317 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0209 | 0.4826 | 0.5433 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0209 | 0.4826 | 0.5433 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0344 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0315 | 0.8884 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0134 | 0.1943 | 0.2188 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0267 | 0.7022 | 0.7316 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.032 | 0.9071 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0134 | 0.1943 | 0.2188 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0315 | 0.8884 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0197 | 0.4344 | 0.4889 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0183 | 0.3835 | 0.4317 |
Echinococcus multilocularis | acetylcholinesterase | 0.0315 | 0.8884 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0315 | 0.8884 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0315 | 0.8884 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0315 | 0.8884 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0315 | 0.8884 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.8884 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0315 | 0.8884 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0197 | 0.4344 | 0.4889 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.8884 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0315 | 0.8884 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.3 ug ml-1 | Minimum inhibitory concentration of the compound was measured against Candida albicans ATCC 10231 using modified Sabouraud dextrose broth; (a) | ChEMBL. | 15664836 |
MIC (functional) | = 6.3 ug ml-1 | Minimum inhibitory concentration of the compound was measured against Aspergillus niger KCTC 1231 using modified Sabouraud dextrose broth; (a) | ChEMBL. | 15664836 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration of the compound was measured against Aspergillus flavus KCCM 11899 using modified Sabouraud dextrose broth; (a) | ChEMBL. | 15664836 |
MIC (functional) | = 25 ug ml-1 | Minimum inhibitory concentration of the compound was measured against Candida tropicalis ATCC 28775 using modified Sabouraud dextrose broth; (a) | ChEMBL. | 15664836 |
MIC (functional) | = 25 ug ml-1 | Minimum inhibitory concentration of the compound was measured against Candida krusei ATCC 749 using modified Sabouraud dextrose broth; (a) | ChEMBL. | 15664836 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.