Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1376 | 0.1895 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.2302 | 0.5292 | 0.5166 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.2518 | 0.6087 | 0.5982 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1376 | 0.1895 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1376 | 0.1895 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.2518 | 0.6087 | 0.5982 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1376 | 0.1895 | 0.1679 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.2302 | 0.5292 | 0.5166 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.1046 | 0.0683 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.086 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1376 | 0.1895 | 0.1679 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1376 | 0.1895 | 0.151 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1376 | 0.1895 | 0.151 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0959 | 0.0363 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.1376 | 0.1895 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1376 | 0.1895 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.086 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.1046 | 0.0683 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1282 | 0.155 | 0.1324 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1376 | 0.1895 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.086 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.3233 | 0.871 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1376 | 0.1895 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.086 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.3584 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1376 | 0.1895 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logP (ADMET) | = 0.356 | Partition coefficient (logP) | ChEMBL. | 15664807 |
MIC (functional) | = 1 ug ml-1 | In vitro minimum inhibiting concentration for the development of ring stage parasite into the schizont stage during 40 h incubation | ChEMBL. | 15664807 |
MIC (functional) | = 1 ug ml-1 | In vitro minimum inhibiting concentration for the development of ring stage parasite into the schizont stage during 40 h incubation | ChEMBL. | 15664807 |
PKa (ADMET) | = 2.58 | In vitro PKa value of the compound was determined | ChEMBL. | 15664807 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.