Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % | |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0164 | 0.3338 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0164 | 0.3338 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0164 | 0.3338 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Echinococcus granulosus | peroxidasin | 0.0164 | 0.3338 | 0.3338 |
Brugia malayi | Animal haem peroxidase family protein | 0.0164 | 0.3338 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0164 | 0.3338 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Brugia malayi | Peroxidasin | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0164 | 0.3338 | 1 |
Onchocerca volvulus | 0.0164 | 0.3338 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0164 | 0.3338 | 0.3338 |
Schistosoma mansoni | lipoxygenase | 0.0245 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0164 | 0.3338 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0164 | 0.3338 | 1 |
Brugia malayi | hypothetical protein | 0.0164 | 0.3338 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0171 | 0.3949 | 0.3949 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Schistosoma mansoni | peroxidasin | 0.0164 | 0.3338 | 0.3338 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0164 | 0.3338 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3338 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0164 | 0.3338 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0164 | 0.3338 | 1 |
Onchocerca volvulus | 0.0164 | 0.3338 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0164 | 0.3338 | 0.3338 |
Onchocerca volvulus | 0.0164 | 0.3338 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.8 uM | Binding affinity against purified rat Fatty-acid amide hydrolase (FAAH) expressed in Escherichia coli | ChEMBL. | 15582420 |
Ki (binding) | = 6.8 uM | Binding affinity against purified rat Fatty-acid amide hydrolase (FAAH) expressed in Escherichia coli | ChEMBL. | 15582420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.