Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0225 | 0.5827 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.034 | 1 | 0.5 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.034 | 1 | 0.5 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.016 | 0.3468 | 0.5951 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.016 | 0.3468 | 0.5951 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0115 | 0.1813 | 0.3111 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0115 | 0.1813 | 0.5229 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0115 | 0.1813 | 0.3111 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0101 | 0.1304 | 0.2238 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.016 | 0.3468 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration of the compound against vancomycin sensitive Enterococci faecium L568 strain was determined | ChEMBL. | 15664849 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration of the compound against vancomycin resistant Enterococci faecium L2215 strain was determined | ChEMBL. | 15664849 |
MIC (functional) | = 128 ug ml-1 | Minimum inhibitory concentration of the compound against vancomycin sensitive Enterococci faecalis L559 strain was determined | ChEMBL. | 15664849 |
MIC (functional) | = 128 ug ml-1 | Minimum inhibitory concentration of the compound against vancomycin resistant Enterococci faecalis L560 strain was determined | ChEMBL. | 15664849 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration of the compound against vancomycin resistant Staphylococcus aureus L613 strain was determined | ChEMBL. | 15664849 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.