Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrilysin homolog | 0.3151 | 0.6712 | 1 |
Brugia malayi | Matrixin family protein | 0.1421 | 0.2915 | 0.461 |
Trichomonas vaginalis | AGC family protein kinase | 0.0148 | 0.0122 | 0.5 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1731 | 0.3594 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0148 | 0.0122 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.0206 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0148 | 0.0122 | 0.003 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0102 | 0.002 | 0.002 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0092 | 0 | 0.5 |
Brugia malayi | Matrixin family protein | 0.1421 | 0.2915 | 0.461 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1421 | 0.2915 | 0.4255 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1421 | 0.2915 | 0.9442 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0513 | 0.0923 | 0.2944 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0117 | 0.0055 | 0.0055 |
Trypanosoma cruzi | Protein kinase B | 0.0102 | 0.002 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0148 | 0.0122 | 0.5 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0102 | 0.002 | 0.002 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0102 | 0.002 | 0.164 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1731 | 0.3594 | 0.5723 |
Toxoplasma gondii | AGC kinase | 0.0139 | 0.0102 | 0.5 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0102 | 0.002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1421 | 0.2915 | 0.4255 |
Brugia malayi | Protein kinase domain containing protein | 0.0148 | 0.0122 | 0.0033 |
Brugia malayi | Matrixin family protein | 0.292 | 0.6203 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0102 | 0.002 | 0.164 |
Trichomonas vaginalis | AGC family protein kinase | 0.0148 | 0.0122 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1731 | 0.3594 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1421 | 0.2915 | 0.4255 |
Brugia malayi | Hemopexin family protein | 0.1499 | 0.3086 | 0.489 |
Loa Loa (eye worm) | matrixin family protein | 0.3151 | 0.6712 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.3151 | 0.6712 | 1 |
Brugia malayi | Matrixin family protein | 0.1421 | 0.2915 | 0.461 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0187 | 0.0208 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0393 | 0.066 | 0.0844 |
Trichomonas vaginalis | AGC family protein kinase | 0.0148 | 0.0122 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0148 | 0.0122 | 0.5 |
Giardia lamblia | Kinase, AGC PKA | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1731 | 0.3594 | 0.5283 |
Echinococcus multilocularis | adam 17 protease | 0.0187 | 0.0208 | 0.0208 |
Entamoeba histolytica | protein kinase, putative | 0.0139 | 0.0102 | 0.836 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0117 | 0.0055 | 0.0055 |
Entamoeba histolytica | protein kinase, putative | 0.0148 | 0.0122 | 1 |
Onchocerca volvulus | 0.1499 | 0.3086 | 0.045 | |
Mycobacterium ulcerans | hydrolase | 0.1731 | 0.3594 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0148 | 0.0122 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1499 | 0.3086 | 1 |
Brugia malayi | Matrixin family protein | 0.1421 | 0.2915 | 0.461 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1421 | 0.2915 | 0.4255 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0148 | 0.0122 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0148 | 0.0122 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.292 | 0.6203 | 0.9231 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.465 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10 ug ml-1 | In vitro inhibitory concentration against Cdc25A protein phosphatase | ChEMBL. | 15582411 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.