Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0035 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0035 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0006 | 0.0543 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0035 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.0051 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.001 | 0.0925 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0035 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0035 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0034 | 0.6709 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.6366 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0079 | 0.0077 | 1 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.1797 | 0.2788 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0099 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.001 | 0.1976 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.6366 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.001 | 0.1313 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.0019 | 0.0019 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.0019 | 0.0019 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0035 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.6366 | 1 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.003 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.001 | 0.1313 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0035 | 0.6952 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.001 | 0.001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0035 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0099 | 0.0109 | 0.0109 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0035 | 0.3254 |
Brugia malayi | jmjC domain containing protein | 0.0099 | 0.0109 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.001 | 0.001 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 3000 nM | Compound was tested for cytotoxicity against paclitaxel sensitive KB-3-1 cell line | ChEMBL. | 15261301 |
IC50 (functional) | > 3000 nM | Compound was tested for cytotoxicity against paclitaxel resistant KB-8-5 cell line expressing P-glycoprotein | ChEMBL. | 15261301 |
IC50 (functional) | > 3000 nM | Compound was tested for cytotoxicity against paclitaxel resistant KB-V1 cell line expressing P-glycoprotein | ChEMBL. | 15261301 |
IC50 (functional) | > 3000 nM | Compound was tested for cytotoxicity against paclitaxel sensitive KB-3-1 cell line | ChEMBL. | 15261301 |
IC50 (functional) | > 3000 nM | Compound was tested for cytotoxicity against paclitaxel resistant KB-8-5 cell line expressing P-glycoprotein | ChEMBL. | 15261301 |
IC50 (functional) | > 3000 nM | Compound was tested for cytotoxicity against paclitaxel resistant KB-V1 cell line expressing P-glycoprotein | ChEMBL. | 15261301 |
Inhibition (functional) | = 27 % | Compound was evaluated for the ability to inhibit cell-free tubulin polymerisation at 0.5 uM | ChEMBL. | 15261301 |
Inhibition (functional) | = 27 % | Compound was evaluated for the ability to inhibit cell-free tubulin polymerisation at 0.5 uM | ChEMBL. | 15261301 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15261301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.