Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1198 | 0.1198 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1472 | 0.1472 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1198 | 0.1198 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0109 | 0.7011 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0072 | 0.4176 | 0.4176 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.7011 | 0.7011 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1198 | 0.1708 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.2583 | 0.3685 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.4169 | 0.4169 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0072 | 0.4176 | 0.4176 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.4169 | 0.5947 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.2583 | 0.2583 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.673 | 0.673 |
Brugia malayi | Transient-receptor-potential like protein | 0.0041 | 0.1751 | 0.1751 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.2583 | 0.2583 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0109 | 0.7011 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0072 | 0.4176 | 0.5956 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0105 | 0.6732 | 0.6732 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.2583 | 0.2583 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.2583 | 0.2583 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.1198 | 0.1198 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 1 | 1 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0041 | 0.1751 | 0.1751 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.1198 | 0.1198 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0072 | 0.4176 | 0.4176 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3896 | 0.3896 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.1198 | 0.1198 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.673 | 0.673 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.4169 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.673 | 0.673 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0041 | 0.1751 | 0.1751 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1198 | 0.1198 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1751 | 0.1751 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.2583 | 0.2583 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1198 | 0.1708 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.2583 | 0.2583 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.673 | 0.673 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.1198 | 0.1198 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0105 | 0.6732 | 0.6732 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.1198 | 0.1198 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.1198 | 0.1198 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0072 | 0.4176 | 0.4176 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1198 | 0.1708 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0109 | 0.7011 | 0.7011 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.2583 | 0.3685 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.1198 | 0.1198 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0072 | 0.4176 | 0.5956 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0109 | 0.7011 | 0.7011 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.2583 | 0.3685 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1198 | 0.1708 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7 M | Tested in vitro against murine L1210 leukemia. | ChEMBL. | 3806589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.